多囊卵巢综合征的临床表现及内分泌变化的研究分析

Analysis of the clinical manifestations and endocrine changes of women with polycystic ovarian syndrome

目的探讨多囊卵巢综合征患者常见的临床表现及内分泌变化情况。方法按照随机双盲原则选取2015年1月至2015年12月于本院确诊为多囊卵巢综合征的患者80例为研究对象,入组患者均常规给予枸橼酸氯米芬联合二甲双胍。比较患者用药前后体内性激素水平变化情况及用药治疗对血糖代谢的影响。结果用药后患者空腹胰岛素水平、胰岛素抵抗指数、临床表现(卵巢体积增大、多毛、痤疮、月经紊乱)均较用药前显著改善(P<0.05),而用药前后空腹血糖水平比较差异无显著性(P>0.05)。结论枸橼酸氯米芬联合二甲双胍能够有效提高多囊卵巢综合征患者的临床疗效,纠正患者高胰岛素血症,并减少胰岛素抵抗,值得临床推广应用。

Objective To explore and research the clinical manifestations and endocrine changes of women with polycystic ovarian syndrome. Method According to the principle of random double-blind, 80 cases of patients who were diagnosed as polycystic ovarian syndrome from January 2015 to December 2015 in our hospital were selected as the objects of the study, all patients were given oral administration clomiphene citrate and metformin, compared and researched the changes of the sex hormone levels of the patients before and after medication and its influence on blood glucose metabolism. Result After treatment, fasting insulin, insulin resistance index, clinical manifestations（ovarian volume, hirsutism, acne, menstruation disorder） of the patients had significantly improved（P〈0.05）, and difference of fasting blood glucose before and after treatment was not statistically significant（P〉0.05）. Conclusion Applying combined drug therapy on polycystic ovarian syndrome patients not only can improve the clinical total effective rate of treatment, but also significantly improve the regulatory hormone level, it is worthy of recommendation and application.