长春市2007-2014年疑似预防接种异常反应报告分析

Analysis on surveillance data of suspected adverse events following immunization in Changchun City, Jilin Province, China in 2007 - 2014

目的分析长春市2007-2014年疑似预防接种异常反应（Adverse Events Following Immunization,AEFI）报告质量及其流行性特征。方法对来自长春市2007年1月-2014年12月的AEFI监测系统的个案数据进行描述分析。结果长春市AEFI报告病例数累计9 841例,6和7月份发生构成比高于其他月份,分别为1 002例（10.57%）和960例（10.13%）,病例主要集中在0和1岁,分别为4 879例（51.46%）和2 542例（26.81%）,异常反应发生率前3位的一类疫苗分别为百日咳-白喉-破伤风联合疫苗（全细胞）（10.28/10万）、麻疹-风疹联合减毒活疫苗（3.12/10万）、麻疹减毒活疫苗（2.19/10万）,二类疫苗分别为水痘减毒活疫苗（2.93/10万）、b型流行性感冒嗜血杆菌结合疫苗（2.42/10万）、流感病毒裂解疫苗（1.94/10万）。结论长春市AEFI的监测敏感性逐年升高,婴幼儿发生比重大,且AEFI发生率高于全国平均水平,应加强相关人员的培训,定期开展AEFI工作督导,确保监测工作质量,提高疫苗接种安全性。

Ob jective To analyze the quality of report and epidemiological characters of suspected Adverse Events Following Immunization（AEFI） in Changchun City, Jilin Province, China in 2007 - 2014. Methods The data from AEFI monitoring system in Changchun from January 2007 to December 2014 were collected and analyzed. Results A total of 9 841 cases of AEFI were reported in Changchun during 2007 - 2014, most of which appeared in June（1 002 cases,10. 57%）and July（960 cases, 10. 13%）, and in the infants at ages of 0（4 879 cases, 51. 46%）and 1 years（2 542 cases,26. 81%）. In the turn of incidences of AEFI induced, the top three vaccines of classes Ⅰ were whole cell DPT（10. 28 /100 000）, live attenuated measles-rubella combined vaccine（MR）（3. 12 / 100 000）and live attenuated measles vaccine（MV）（2. 19 / 100 000）, while the top three vaccines of class Ⅱ were live attenuated varicella vaccine（2. 93 / 100 000）,Haemophilus influenza type b vaccine（Hib）（2. 42 / 100 000）and influenza virus split vaccine（Flu）（1. 94 / 100 000）.Conclusion The sensitivity of AEFI monitoring in Changchun increased year by year. AEFI mainly appeared in infants.The incidence of AEFI in Changchun was higher than the national average. Relevant personnel training should be strengthened, and the AEFI supervise should be conducted regularly so as to ensure the quality of monitoring and improve the safety of vaccination.