fFN(胎儿纤维连接蛋白)定量临床观察研究

Fetal Fibronectin Quantitative Clinical Observations and Research

目的:观察f FN(胎儿纤维连接蛋白)浓度与早产发生的相关性,评估其对降低早产的发生机率的作用。材料与方法:将我院2014年至2016年,建卡2000名孕妇孕24-34周入组,根据有无先兆早产症状分2组,无症状组和有症状组,进行早产风险由低到高评分,每个病例入组后进行2次或多次f FN浓度检测并记录。观察f FN浓度及分娩结局。结果:2000例研究对象,共发生早产的83例,早产发生率4.15%,有症状组700例,f FN≥50ng/ml78例,发生早产68例,无症状组1300例,f FN≥50ng/ml28例,发生早产9例。两组f FN≥50ng/ml 106个,发生早产77例,发生率72.6%,f FN<50ng/ml1896个,发生早产的6例,早产发生率0.31%。f FN浓度<50ng/ml,不分娩的阴性预测值99.67%;f FN≥50ng/ml,分娩阳性预测值72.64%。f FN≥50ng/ml和宫颈长度≤25mm同时异常预测早产发生的敏感性为81.23%。结论:应用f FN快速浓度检测可以科学、准确对早产进行管理;f FN浓度越高孕妇早产的风险显著增加,需要进行积极有效的医学干预;f FN浓度低的患者早产风险明显降低,可减少过度干预和孕妇精神压力。f FN定量检测较定性检测对于早产的预测诊断更有意义。

Purpose： To observe the concentration of Fetal Fibronectin（ f FN） in relation to premature labour,and to evaluate its effectiveness in reduction of premature labour rate. Materials and Methods： A total of two thousand pregnant women were recruited between 24 weeks to 34 weeks pregnancy from year 2014 to year 2016 in our hospital. They were assigned into two groups： a group with premature labour symptoms,and a group without premature labour symptoms. The risk of premature labour scored from low to high after grouped each participant. The f FN concentrations were tested twice or more and then recorded,so as to observe the f FN concentration and birth outcomes. Results： 2000 cases of the research object,a total of 83 cases of premature,4. 15% incidence of preterm birth,symptomatic group 700 examples,f FN 50 or more ng / ml78 cases,68 cases of preterm birth occurred,asymptomatic group 1300 examples,f FN acuity 50 ng / ml28 example,9 cases of preterm delivery. Two groups f FN acuity 50 ng / ml,106,77 cases of preterm birth occurred,the incidence of 72. 6%,f FN 50 ng / ml1896,6 cases of preterm delivery,premature birth incidence rate of 0. 31%. FFN concentration 50 ng / ml,not the negative predictive value of 99. 67% of delivery; FFN 50 ng / ml,or childbirth positive predictive value of 72. 64%. FFN acuity ng / ml and 50 cervical length of 25 mm or less abnormal predicting preterm births occur at the same time the sensitivity of81. 23%. Conclusion： The f FN fast concentration detection can be use in managing premature labour scientifically and effectively; the higher the f FN concentration,the more risk the premature labour will be,therefore it would need effective medical intervention; the lower the f FN concentration,the lower risk of premature labour,these will lead to reduced medical intervention and reduced level of pregnancy related anxiety and pressure. The f FN concentration quantitative level detection has more significance than the f FN qualitative detection.