超微血管成像技术对斑块内新生血管的检测及危险因素分析

An Assessment of Plaque Neovascularization Using Superb Micro-vascular Ultrasound Imaging and Analysis of the Risk Factors

目的应用超微血管成像技术（SMI）对颈动脉斑块内新生血管进行评估,并对相关危险因素进行分析。方法对普通二维多普勒超声检查发现颈动脉斑块（至少一处斑块厚度〉2.5 mm或长度〉10.0 mm）者,进一步行SMI检查,并详细记录患者的基线临床资料及检查结果进行分析。结果共计63例患者进行SMI检查（男性39例,女性24例）,检出斑块内新生血管形成45例（71.43%）。对可能的相关危险因素进行多因素Logistic回归分析发现：冠心病史（OR=6.07,95%CI：1.08~34.22）、脑梗死病史（OR=13.04,95%CI：2.80~60.70）、高水平的低密度脂蛋白胆固醇（OR=7.57,95%CI：2.20~26.09）和C反应蛋白（OR=1.72,95%CI：1.26~2.35）是斑块内新生血管形成的危险因素（P〈0.05）。结论 SMI可以用于检测斑块内新生血管形成。男性、冠心病史、脑梗死病史、高水平低密度脂蛋白胆固醇和C反应蛋白是斑块内新生血管形成的危险因素。

Aim To evaluate the carotid intra-plaque neovascularization using superb micro-vascular ultrasound imaging（SMI） and analyze the risk factors which related to the intra-plaque neovascularization. Methods Patients who were found at least one carotid artery plaque thicker than 2.5 mm or longer than 10.0 mm were taken the examination of SMI. All the baseline information and results of examination were recorded. Results There were 63 patients who took the examination of SMI（male 39, female 24）, 45（71.43%） cases of them were found neovascularization in their plaques. Multiple Logistic regression analysis of risk factors showed that the history of coronary disease（OR=6.07,95% CI：1.08~34.22）and cerebral infarction（OR=13.04,95% CI：2.80~60.70）, higher level of LDL-C（OR=7.57,95% CI：2.20~26.09） and CRP（OR=1.72,95% CI：1.26-2.35） were risk factors of intra-plaque neovascularization（P0.05）. Conclusion The technology of SMI can be used in detecting the carotid intra-plaque neovascularization. The history of coronary heart disease and cerebral infarction, higher level of LDL-C and CRP were risk factors of intra-plaque neovascularization.