诱捕受体3在鼻咽癌中的表达及临床意义

Expression and clinical significance of decoy receptor 3 in nasopharyngeal carcinoma

目的研究诱捕受体3(Dc R3)蛋白在鼻咽癌中的表达及临床意义。方法采用免疫组织化学(SABC法)检测40例鼻咽癌组织中Dc R3蛋白的表达情况,同时与40例正常鼻咽黏膜组织进行对照。结果鼻咽癌组织中Dc R3蛋白的表达(-)6例,(+)24例,(++)10例;正常鼻咽黏膜组织中Dc R3蛋白的表达(-)26例,(+)11例,(++)3例;鼻咽癌组织中Dc R3蛋白的表达明显高于正常鼻咽黏膜组织,差异具有统计学意义(P<0.05);Dc R3蛋白的表达与鼻咽癌组织的分化程度、临床分期、淋巴结转移有关(P<0.05),与年龄、性别无关(P>0.05)。结论 Dc R3蛋白在鼻咽癌组织的高表达,可作为判断鼻咽癌分化、浸润、转移的重要指标。

Objective To research expression and clinical significance of decoy receptor 3（DcR3） protein in nasopharyngeal carcinoma. Methods Expression of DcR3 protein in 40 nasopharyngeal carcinoma tissues were detected by immunohistochemical SABC test, and they were compared with 40 normal nasopharyngeal mucosa tissues. Results Expression of DcR3 protein in nasopharyngeal carcinoma tissues included（-） 6 cases,（＋） 24 cases and（＋＋） 10 cases, and it in normal nasopharyngeal mucosa tissues were as（-） 26 cases,（＋） 11 cases and（＋＋） 3 cases. Nasopharyngeal carcinoma tissues showed obviously higher expression of DcR3 protein than normal nasopharyngeal mucosa tissues, and the difference had statistical significance（P0.05）. Expression of DcR3 protein is correlated with differentiated degree, clinical stages and lymphatic metastasis of nasopharyngeal carcinoma tissues（P0.05）, while it had no correlated with age and gender（P0.05）. Conclusion High expression of DcR3 protein in nasopharyngeal carcinoma tissues can be taken as an important indicator for judging differentiation, infiltration and metastasis of nasopharyngeal carcinoma.