高压氧治疗对帕金森病患者日常生活活动能力影响的临床观察

Clinical observation on the effects of hyperbaric oxygen on the daily life capability of the patients with Parkinson＆#39;s disease

目的：探讨高压氧（hyperbaric oxygen，HBO）治疗对帕金森病（Parkinson disease，PD）患者日常生活活动能力的影响。方法60例接受高压氧治疗的 PD 患者分别于治疗前及治疗4个疗程后应用帕金森病生活质量问卷（Parkinson＇s disease questionnaire，PDQ-39）评价 PD 患者生活质量；采用统一帕金森病评定量表（unified Parkinson＇s disease rating scale，UPDRS）和 Hoehn-Yahr（H-Y）分级评价运动功能，同时记录治疗前后的多巴胺类药物剂量及其变化，并对相关结果进行配对 t 检验。结果高压氧治疗4个疗程后 PDQ-39总分较治疗前有明显减少（P ＜0．05），其中运动、日常生活活动（ADL）、情感状态、身体不适等亚项评分改善最为明显（P ＜0．05）；“关”状态下 UPDRSⅢ评分（31．6±10．2）及 H-Y 分级（2．8±0．3）均较治疗前（45．3±6．2，3．2±0．5）有明显减轻（P ＜0．05）；治疗后多巴胺类药物减少18．9％（P ＜0．05）。结论高压氧治疗可以明显提高帕金森病患者的日常生活活动能力。

Objective To investigate the effects of hyperbaric oxygen （HBO）on the daily life activity of the patients with Parkinson＇s disease （PD）.Methods The life quality of 60 PD patients who underwent HBO therapy was assessed both before therapy and after 4 courses of HBO therapy by using the Parkinson＇s Disease Questionnaire-39 （PDQ-39）.Unified Parkinson＇s Disease Rating Scale （UPDRS）and Hoehn-Yahr Scale were applied to evaluate the motor function.At the same time,the dosage and changes in the levels of dopaminergic drugs both before and after HBO therapy were recorded and the derived results were assessed with t-test.Results The total PDQ-39 scores were significantly elevated after 4 courses of HBO therapy,as compared with those before therapy （P 〈0.05 ）.Of all the indicators,mobility,activities of daily living （ADL）,emotional status and bodily discomfort were most significantly improved as compared with those before therapy（P 〈0.05）.At of status,UPDRS III scores （31.6 ±10.2）and Hoehn ＆ Yahr scale scores （2.8 ± 0.3）were all decreased significantly,as compared with those（45.3 ±6.2,3.2 ±0.5）before HBO therapy （P 〈0.05 ）.The daily dosage of dopaminergic drugs was reduced by 18.9% after therapy （P 〈0.05 ）. Conclusions HBO therapy could significantly improve the daily life activity of the patients with PD.