幽门螺杆菌根除失败后两种四联方案根除率的疗效对比

Clinical effect of two quadruple therapies on patients with Helicobacter pylori eradication failure

[目的]探讨两种四联方案应用在幽门螺杆菌根除失败的患者中的临床疗效及应用价值。[方法]选择我院进行幽门螺杆菌根除失败患者102例采取随机数字表法分为观察组和对照组,对照组给予以四环素为主的四联方法补救治疗,观察组采取以莫西沙星为主的四联方案补救治疗,记录治疗情况。[结果]观察组治疗总有效率为86.27%,对照组治疗总有效率为64.71%,组间对比差异有统计学意义(χ2=6.4114,P<0.05)。观察组治疗后白细胞介素-6(13.18±1.33)mg/L,白细胞介素-10(23.86±5.16)mg/L;对照组治疗后白细胞介素-6(23.16±2.47)mg/L,白细胞介素-10(14.15±4.09)mg/L,组间对比差异有统计学意义(t=25.4059、10.5315,P<0.05)。观察组幽门螺杆菌清除率78.43%,高于对照组幽门螺杆菌清除率56.86%,组间对比差异有统计学意义(χ2=5.4203,P<0.05)。2组不良反应比较差异无统计学意义(χ2=0.4435,P>0.05)。[结论]莫西沙星、雷贝拉唑、阿莫西林联合胶体果胶铋的四联方案应用在幽门螺杆菌根除失败患者中是一种有效的补救治疗方法,能够改善患者炎症状态,效果可靠,值得在临床大力推广使用。

[Objective]To investigate the clinical curative effect of two kinds of quadruple therapies in the treatment of patients with Helicobacter pylori eradication failure.[Methods]102cases of patients with helicobacter pylori eradication failure were divided into observation group and control group randomly.The former was given quadruple therapy based on moxifloxacin as remedial treatment.The latter was given quadruple therapy based on tetracycline.Curative effect was observed.[Results]The total effective rate of the observation group was 86.27%,which was significantly higher than that of the control group,64.71%（P〈0.05）.After the treatment,interleukin-6level in the observation group and the control group was13.18 ± 1.33mg/L and 23.16 ± 2.47 mg/L respectively,interleukin-10 level was 23.86 ±5.16 mg/L and 14.15±4.09mg/L respectively,the difference between the two groups was statistically significant（P〈0.05）.The helicobacter pylori clearance rate of the observation group was 78.43%,higher than that of the control group,56.86%,（P〈0.05）.The adverse reaction was similar between the two groups,with no statistically significant difference（chi-square=0.4435,P〉0.4435）.[Conclusion]Quadruple therapy of moxifloxacin,rabeprazole combined with Colloidal bismuth pectin and amoxicillin applied in patients with helicobacter pylori eradication failure was effective in improving inflammatory state of the patients,deserving to be popularized in clinical application.