脾胃培源方对脾胃虚弱型慢性萎缩性胃炎的临床疗效及理化指标的影响

Effect of Piwei Peiyuan Decoction on chronic atrophic gastritis with the type of spleen-stomach deficiency and its effect on physicochemical index

[目的]观察脾胃培源方对脾胃虚弱型慢性萎缩性胃炎(CAG)的临床疗效及理化指标的影响,为临床治疗提供参考依据。[方法]将60例脾胃虚弱型CAG患者,随机分为治疗组和对照组,各30例。治疗组予中药脾胃培源方内服,对照组予中成药胃复春口服,3个月为1个疗程。治疗1个疗程后,对2组临床疗效、血清胃蛋白酶原数值及病理积分情况进行评价。[结果]治疗组总有效率为96.67%,对照组总有效率为76.67%,治疗组优于对照组,差异有统计学意义(P<0.05)。2组治疗后血清胃蛋白酶原(PG)数值都得到改善,与治疗前比较,差异有统计学意义(P<0.01,P<0.05),与对照组比较差异有统计学意义(P<0.05)。2组治疗后病理量化积分均下降,与治疗前比较,差异有统计学意义(P<0.05),与对照组比较疗效相当,差异无统计学意义(P>0.05)。[结论]脾胃培源方能有效缓解脾胃虚弱型CAG患者的临床症状,明显改善理化指标,临床疗效安全可靠,值得临床上推广与应用。

[Objective]To observe the therapeutic effects and the influence of laboratory data of Piwei Peiyuan decoction（PPD）for the spleen-stomach deficiency type of chronic atrophic gastritis,so as to provide a reference for the clinical treatment.[Methods]A total of 60 chronic atrophic gastritis patients with the type of spleen-stomach deficiency were randomly divided into treatment group and control group randomly.Each group contained 30 cases.The patients in the treatment group were treated with PPD,while the control group with Weifuchun tablets.The treatment course was three months in each group.After one course,the clinical efficacy level,pathological integration and serum pepsinogen level were compared respectively.[Results]The overall clinical effectiveness rate was 96.67%in the treatment group,which was higher than 76.67%in the control group.The difference showed statistical significance（P〈0.05）.After the treatment,serum pepsinogen level in the two groups all improved（P0.01,P〈0.05）.Compared with the control group,the serum pepsinogen level significantly improved（P〈0.05）.The pathological integration in the two groups were lower than before the treatment（P〈0.05）,with statistical significance.The difference between the two groups in pathological integration had no statistical significance（P〉0.05）.[Conclusion]PPD showed good clinical effect in treating chronic atrophic gastritis of spleen-stomach deficiency with the laboratory data improved significantly.PPD is worthy of clinical promotion and applicationdue to its efficacy and safety.