期刊文献+

凝血因子X和蛋白酶Factor Xa的机理研究概况 被引量:2

下载PDF
导出
摘要 血液凝固是一个复杂但又奇妙的过程。本文概述了血液凝固机制和凝血酶形成,着重阐述了介绍了凝血因子X的生化特性、分子蛋白结构、激活剂鲁塞尔蝰蛇毒X和具有重要应用价值的激活态蛋白酶Factor Xa。本文通过对凝血因子X和蛋白酶Factor Xa结构与功能及其相互关系的深入理解,为它们基础研究及工业化生产应用提供了一定的理论依据。
作者 黄晶
出处 《海峡药学》 2016年第7期266-269,共4页 Strait Pharmaceutical Journal
  • 相关文献

参考文献11

  • 1B Keren,S C Arnold.Blood coagulation factor Xa as an emerging drug target[J].Expert Opinion on Therapeutic Targets,2011,15(3):341-349.
  • 2M Nigel,RE Tilley,NS Key.Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis[J].Arteriosclerosis Thrombosis&Vascular Biology,2007,27(8):1687-1693.
  • 3Q Lu,L Yang,C Manithody,X Wang,et al.Molecular basis of the clotting defect in a bleeding patient missing the Asp-185 codon in the factor X gene[J].Thrombosis Research,2014,134(5):1103-1109.
  • 4S Rana,L Yang,SM Hassanian,AR Rezaie.Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombin[J].Journal of Cellular Biochemistry,2012,113(3):977-984.
  • 5M Marzia,V Anna,P Roberta,M Giuseppe,C Luigi,et al.A recurrent Gly43Asp substitution in coagulation Factor X rigidifies its catalytic pocket and impairs catalytic activity and intracellular trafficking[J].Thrombosis Research,2013,133(3):481-487.
  • 6J Xing,L Yang,H Li,Q Li,L Zhao,et al.Identification of anthranilamide derivatives as potential factor Xa inhibitors:Drug design,synthesis and biological evaluation[J].European Journal of Medicinal Chemistry,2015,95:388-399.
  • 7FS Markland,S Swenson.Snake venom metalloproteinases[J].Toxicon Official Journal of the International Society on Toxinology,2013,62(62):3-18.
  • 8M Suntravat,I Nuchprayoon,JC Pérez.Comparative study of anticoagulant and procoagulant properties of 28 snake venoms from families Elapidae,Viperidae,and purified Russell’s viper venom-factor X activator(RVV-X)[J].Toxicon:Journal of the International Society on Toxinology,2010,56(4):544-553.
  • 9RJ Jenny,KG Mann,RL Lundblad.A critical review of the methods for cleavage of fusion proteins with thrombin and factor Xa[J].Protein Expression&Purification,2003,31(1):1-11.
  • 10余榕捷,高媛,洪岸.提高Xa因子酶切效率的策略[J].中国生物工程杂志,2004,24(12):84-88. 被引量:4

二级参考文献3

共引文献3

同被引文献15

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部