消癌平注射液对乳腺癌患者术后免疫功能的影响

Effects of XiaoaipingInjection on the Immune Function in Patients with Breast Cancer After Operation

目的:探讨消癌平注射液对乳腺癌患者术后免疫功能的影响。方法:选取2013年6月至2015年7月84例术后乳腺癌患者,随机分为对照组(n=42)及观察组(n=42)。两组在术后同时行CMF[环磷酰胺(CTX)+甲氨蝶呤(MTX)+氟尿嘧啶(5-FU)]化疗方案。对照组仅行化疗治疗,观察组在对照基础上静脉滴注消癌平注射液。对比分析两组患者的治疗效果、术后免疫功能、炎症因子及血管内皮生长因子(VEGF)水平的变化。结果:观察组患者治疗后Th17细胞比率低于对照组,而Th17/Treg、CD4^+CD25^+Treg细胞的比率则高于对照组(P<0.05)。观察组患者术后白细胞介素(IL)-1,6、肿瘤细胞坏死因子-α(TNF-α)及VEGF水平显著低于对照组(P<0.05)。结论:消癌平注射液能有效改善乳腺癌化疗患者的免疫功能,降低化疗对患者的毒副作用,提高治疗效果。

Objective：To investigate the effects of Xiaoaipinginjection,a traditional Chinese medicine,on the immune function in patients with breast cancers after operation.Methods：84cases of breast cancer undergoing chemotherapy after operation were randomly divided into control group（n=42）and observation group（n=42）from June 2013 to July 2015.All the patients in the control group were treated with CMF,cyclophosphamide（CTX）＋ methotrexate（MTX）＋ fluorouracil（5-FU）,and those in the observation group were treated with Xiaoaipinginjection＋ CMF.The levels of postoperative immune function,inflammatory factors and VEGF of the two groups were compared.Results：The levels of Th17 of the observation group were lower than those of the control group,whereas the levels of Th17/Treg and the levels of CD4~＋CD~＋ 25Treg cells of the observation group were higher than those of the control group（P〈0.05）.Moreover,the levels of interleukin-1,-6,tumor necrosis factor-α（TNF-α）and VEGF of the observation group were obviously lower than those of the control group（P〈0.05）.Conclusion：Xiaoaipinginjection can effectively improve the immune function in breast cancer patients with chemotherapy,reduce side effects,and improve therapeutic effect.