子宫内膜异位症患者血清CA_(125)、TNF-α和HE4的表达及联合检测意义

Serum Levels of CA125,TNF-Alpha and HE4,and Their Value in the Diagnosis of Endometriosis

目的:探讨子宫内膜异位症(EMT)患者血清中癌抗原125(CA_(125))、肿瘤坏死因子-α(TNF-α)和人附睾分泌蛋白4(HE4)的表达及其联合检测的临床意义。方法:2010年2月至2015年2月,选择EMT患者97例,作为病例组;选择同时期健康体检者120例,作为对照组。检测对照组和病例组患者治疗前血清中CA_(125)、TNF-α和HE4的水平,并计算病例组CA_(125)、TNF-α、HE4单独检测和联合检测的敏感度和特异度。结果:病例组患者血清中CA_(125)、TNF-α和HE4的水平均高于对照组(t=37.62,P<0.05;t=14.60,P<0.05;t=21.66,P<0.05);同时,随着EMT分级升高,CA_(125)、TNF-α和HE4的水平越高,Ⅲ-Ⅳ期患者均高于Ⅰ-Ⅱ期(t=14.17,P<0.05;t=5.87,P<0.05;t=14.84,P<0.05);联合检测CA_(125)、TNF-α、HE4的敏感度和特异度均高于单独检测,差异均有统计学意义(P<0.05)。结论:EMT患者血清中CA_(125)、TNF-α和HE4的水平均高于正常人群,且EMT分级越高,三项指标的表达水平越高;联合检测CA_(125)、TNF-α、HE4可提高诊断EMT的敏感度和特异度。

Objective：To explore the serum expression of cancer antigen125（CA_（125））,tumor necrosis factor-alpha（TNF-α）and human epididymis protein 4（HE4）and their clinical value of allied detection for diagnosis of endometriosis（EMT）.Methods：Between February 2010 and February2015,97 patients with EMT were selected as case group,120 healthy controls of the same time were chosen as control group.The levels of CA_（125）,TNF-αand HE4 in serum of subjects of the control group and case group were detected before the treatment.The sensitivity and specificity of alone detection and allied detection with CA_（125）,TNF-α,and HE4 of the case group were calculated.Results：The level of serum CA_（125）,TNF-αand HE4 of the patients in case group were higher than those in control group（t=37.62,P〈0.05;t=14.60,P〈0.05;t=21.66,P〈0.05）.Meanwhile,the levels of CA_（125）,TNF-αand HE4 were higher with higher EMT classification.And the levels of CA_（125）,TNF-αand HE4 of patients withⅢ-Ⅳstage were higher than that respectively ofⅠ-Ⅱstage（t=14.17,P〈0.05;t=5.87,P〈0.05;t=14.84,P〈0.05）.In allied detection,the sensitivity and spe-cificity were higher than those in alone detection of serum CA_（125）,TNF-αor HE4,and the difference had statistical significance（P〈0.05）.Conclusion：The levels of serum CA_（125）,TNF-αand HE4 of the EMT patients are higher than the healthy group.The higher EMT classification,the higher the three indicators levels.Allied detection of the CA_（125）,TNF-αand HE4 improves sensitivity and specificity for diagnosis in endometriosis.