摘要
长链非编码RNA（ long noncoding RNA,lncRNA）在生命活动中具有重要的调节作用,其表达紊乱与多种疾病密切相关。已有研究表明,lncRNA可通过转录、转录后及表观遗传修饰水平来调节内分泌及代谢过程,但具体机制仍不十分清楚,尚需进一步的研究去揭示。本文就目前lncRNA在内分泌及代谢中的重要作用做一简要阐述。
[Summary] Long noncoding RNA（ lncRNA） plays an important role in regulating the life activities, and its disordered expression is closely related to many diseases. Several studies have shown that lncRNA could modulate the endocrine metabolic processes at transcription, post-transcription, and the epigenetic modification levels, but the exact mechanism is still unclear. Further research needs to be done. This review will briefly describe the research progress of lncRNAs in endocrine and metabolic respects.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2016年第7期613-616,共4页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金项目（81471069）
