炔丙基胺类化合物的绿色合成

Green Synthesis of Propargyl Amine Derivatives

研究了在离子液体介质中,在碘化亚铜催化下通过芳香醛、胺和炔烃的三组分偶联反应高效合成炔丙基胺衍生物。研究发现,与普通加热相比,微波辐射可明显提高反应速度,并使反应在温和的条件下顺利完成。另外,所使用的铜催化剂和作为溶剂的离子液体可以方便地回收再利用,从而为炔丙基胺类化合物的合成找到了一条绿色、经济、高效的新方法。

A facile, convenient and green one-pot tandem synthesis of propargyl amine derivatives, using copper （I） iodide as catalyst, ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborat （[ bmim] BF4） as reaction medium under the microwave assistance, was achieved. It involved three-component reaction of amines, aromatic aldehyde and alkyne. This method has the advantage of high reaction rate, low cost, no pollution, good yields and recyclability of catalyst and reaction medium.