瑞舒伐他汀联合地尔硫卓对急性心肌梗死患者直接PCI治疗的心肌保护作用

Protection of Rosuvastatin combined with Diltiazem in patients with AMI undergoing percutaneous coronary intervention

目的探讨瑞舒伐他汀联合地尔硫卓对急性心肌梗死患者直接PCI治疗的心肌保护作用。方法选择急性ST段抬高型心肌梗死并行直接PCI术患者150例,随机分为A组(n=72)和B组(n=78)。A组术前口服瑞舒伐他汀联合持续静脉泵入并术中梗死相关动脉内注射地尔硫卓;B组术前口服瑞舒伐他汀联合单纯术中梗死相关动脉内注射地尔硫卓。术前及术后检测两组生化指标、TIMI血流分级及术后90 min ST段回降率。结果术后两组反映心肌损伤的生化指标较术前均有下降,但A组优于B组(P<0.05);两组治疗后TIMI血流达3级的比例及90 min ST回降率明显升高,A组更为明显(P<0.05)。结论瑞舒伐他汀联合持续静脉泵人并术中梗死相关动脉内注射地尔硫卓可明显减轻PCI术中心肌损伤。

Objective To discuss the myocardial protection of Rosuvastatin combined with Dihiazem in patients undergoing percutaneous coronary intervention （PCI）. Methods 150 patients with acute myocardial infarction （AMI） undergoing PCI were divided into group A （n = 72） and group B （n = 78 ）.Both groups received high- dose rosuvastatin befor PCI and diltiazem by injecting intrainfarct-related artery, group A received dihiazem through continuous intravenous infusion additionally.The biochemical indexes,Thrombolysis In Myocardial Infarc- tion （TIMI） and ST segment drop rate after 90 minutes were counted.Results Compared with the group B, the bochemical indexes decreased and rate of TIMI3, ST segment drop rate after 90 minutes increased obviously in group A. Conclusion High-dose rosuvastatin combined with dihiazem injection intrainfarct-related artery and in- travenous infusion can protect myocardial.