代谢组学在恶性肿瘤诊断中的应用研究进展

Advances on research of metabolomics in malignant cancer diagnosis

近年来代谢组学研究成为疾病诊断、疾病机制研究等的有力手段,对于生物代谢物变化的研究思想已被广泛接受。本文总结了近年来代谢组学研究在恶性肿瘤诊断中的应用,将近几年国内外代谢组学在恶性肿瘤诊断方面相关文献按病种进行归纳整理、总结分析。目前代谢组学用于肿瘤诊断主要集中在胃癌、肝癌、肺癌、食管癌、乳腺癌、卵巢癌、前列腺癌等。代谢组学在恶性肿瘤的发病机制、早期诊断、鉴别诊断、分期及预后判断方面均显示出巨大的发展潜力。随着分析技术的不断发展和完善,代谢组学将成为恶性肿瘤研究的重要手段。

Metabolomics for biological metabolite changes was widely accepted,the study of metabolomics is be- coming a powerful tool for disease diagnosis and disease mechanism in recent years.In this paper, we review the recent applications of metabonomics study in the diagnosis of malignant tumor.Literatures about the study of meta- bonomics in the diagnosis of malignant tumor were summarized according to the classification of tumors.In recent years, metabolomics is widely used in cancer diagnosis, mainly in gastric cancer, liver cancer, lung cancer, esoph- ageal cancer, breast cancer, ovarian cancer, prostate cancer, et al.Metabolomics play important role in the aspects of cancer pathogenesis, early diagnosis, differential diagnosis, staging and prognosis. With the development of anal- ysis techniques, metabolomics will become an important method in the research of malignant tumor.