CD68和Sema 4D蛋白在胃癌组织中的表达相关性及临床意义

Correlation and clinical significance of expressions of CD68 and Sema4D in gastric carcinoma

目的:比较肿瘤相关巨噬细胞(TAMs)标记抗原CD68和轴突导向因子4D(Sema4D)在胃癌组织和正常组织中的表达,探讨两者之间的相关性及临床意义。方法:采用免疫组织化学SP法检测86例胃癌组织和癌旁正常组织中CD68和Sema4D的表达,并分析其与临床病理特征的关系。结果:胃癌组织中CD68和Sema4D蛋白阳性表达率显著高于癌旁组织(72.1%vs23.3%和74.4%vs29.1%,均P<0.01)。CD68和Sema4D蛋白与胃癌组织分化类型、TNM分期和淋巴结转移明显相关(P<0.05),且两者表达呈正相关(r=0.467,P<0.01)。结论:胃癌组织中CD68和Sema4D表达明显增高,且呈显著正相关,两者的联合检测有助于预测胃癌的发展趋势。

Objective： To compare the expressions of CD68 and Semaphorin4D（Sema4D） ingastric carcinoma and normal tissues to investigate the correlation between them and clinical significance. Methods： The expressions of CD68 and Sema4D were examined in 86 cases of gastric carcinoma and adjacent tissues by SP immunohistochemical staining. The relationship between the ex pressions and clinical pathological characters was analysied. Results： The positive rates of CD68 and Sema4D in gastric carcinoma tissues were significant higher than those in adjacent tissues （72.1% vs 23.3%, 74.4% vs 29.1%, respectively; both P〈0.01）. CD68 and Sema4D were closely correlated with gastric carcinoma histological types, TNM stages and lymphatic metastasis （all P〈0. 05）, and a significant correlation was observed between the expression of CD68 and Sema4D pro- teins in gastric carcinoma with the Spearman rank correlation （r=0.467, P〈0.01）. Conclusion： The positive expression of CD68 is strongly correlated with that of Sema4D. Combined detection of CD68 and Sema4D has the potential to be the basis for prediction of the development trend of gastric carcinoma.