ABO血型与丙型肝炎病毒易感性及病毒载量关系的研究

Study on relationship between ABO blood type and susceptibility of HCV virus and HCV RNA load

目的 探讨ABO血型与丙型肝炎病毒（HCV）易感性和血清HCV-RNA载量的关系。方法 选择2014年2月至2016年2月本院感染科门诊及住院的HCV感染者208例作为研究组研究对象;ABO血型采用全自动卡式微孔柱离心法,HCVRNA采用荧光定量PCR技术。随机选择同期体检的健康人群198例作为对照组。结果 不同血型患者HCV感染率及HCV病毒载量比较,差异无统计学意义（χ~2=3.17、3.69,P〉0.05）;不同性别HCV感染率比较,差异无统计学意义（χ~2=0.08,P〉0.05）;不同年龄段HCV感染率比较,差异有统计学意义（χ~2=33.69,P〈0.05）。结论 ABO血型与HCV感染率及HCV病毒载量之间没有关系,中老年患者HCV感染率较高,可为临床预防HCV感染提供有价值的参考。

Objective To explore the relationship between ABO blood type and the susceptibility of hepatitis C virus（HCV） and HCV‐RNA load in serum .Methods Peripheral blood was collected from 208 patients with HCV infection as the research group in our hospital from February 2014 to February 2016 .The ABO blood group was detected by automatic cassette microbore column centrifugation ,and HCV RNA by quantitative polymerase chain reaction（PCR） technique .Contemporaneous 198 individuals under‐going physical examination were selected as the control group .Results The HCV infection rates and HCV RNA load had no statis‐tical differences among different blood groups （χ2 =3 .17 ,3 .69 ,P〉0 .05） .The HCV infection rates had no statistical difference be‐tween different sexes （χ2 =0 .08 ,P〉0 .05） .The HCV infection rates had statistical difference among different age groups （χ2 =33 .69 ,P〈0 .05） .Conclusion There is no relationship between the ABO blood types with the HCV infection rate and HCV RNA load ,the middle age and elderly patients have higher HCV infection rate ,which can provide valuable reference for clinical prevention of HCV infection .