妊娠相关血浆蛋白A在初产妇妊娠期糖尿病中的应用价值

Application value of serum pregnancy-asscociated plasma protein A in primiparous women of gestational diabetes mellitus

目的探讨初产妇孕早期血清中的妊娠相关血浆蛋白A(PAPP-A)水平与妊娠期糖尿病(GDM)发生的关系。方法用非参数检验及Logistic回归分析对168例GDM孕妇及273例健康孕妇的年龄、体质量、PAPP-A、游离β人绒毛膜促性腺激素(fβ-HCG)水平进行回顾性分析。结果 GDM组年龄与对照组差异有统计学意义(P<0.01),PAPP-A浓度及PAPP-A MoM均明显低于对照组,差异有统计学意义(P<0.01)。结论初产妇孕早期低水平PAPP-A与GDM强相关,并可作为GDM的危险因素。

Objective To assess the correlation between the pregnancy-associated plasma protein A（PAPP-A）level with gestational diabetes mellitus（GDM）in primiparous women.Methods The nonparametric test and Logistic regression analysis were used to retrospectively analyze 168 pregnant women of GDM and 273 normal pregnant women,including age,body weight,PAPP-A,freeβ-human chorionic gonadotropin（fβ-hCG）.Results The age had significant difference between GDM group and control group（P〈0.01）,the PAPP-A concentration and corrected multiple of the median（MoM）of PAPP-A in the GDM group were significantly lower than those in the control group（P〈0.01）.Conclusion Low level of PAPP-A during early pregnant stage in primiparas is strongly associated with GDM and can be used as the risk factor of GDM.