摘要
1目的观察自拟三仙汤降低结直肠癌术后CapeOX（Capecitabine＋Oxaliplatin）方案化疗毒副作用的临床疗效。方法纳入符合标准的术后化疗患者（2014年4月～2015年4月）73例，其中治疗组35例，对照组38例，治疗组在化疗过程中口服中药“自拟三仙汤”，对照组正常行CapeOX化疗。观察患者末梢神经毒性（Neurotoxieity symptoms）以及手足综合征（Hand-foot syndrome，HFS）发病情况（分级、分布）、化疗次数与HFS的发生率、化疗完成情况。结果治疗组的末梢神经毒性、手足综合征发病率均低于对照组，治疗组35例，共23例（65．7％）患者手足的末梢神经出现麻木等异常表现，而对照组为38例，其中33例（86．8％）患者的手足末梢神经感觉出现异常，两组比较差异有统计学意义（P=0．031〈0．05o化疗3次后对照组患者HFS发病明显超过治疗组（P=0．0001〈0．01），以I度、Ⅱ度手足综合征偏多。结论自拟三仙汤可提高患者化疗的耐受性，降低HFS及周围神经毒性的发病率。
Objectiye To observe the clinical efficacy of serf-prescribed Sanxian soup on reducing the toxic and side effects of CapeOX （Capecitabine ＋Oxaliplatin） chemotherapy after colorectal cancer surgery. Methods Postoperative chemotherapy patients who met the standards were included （April 2014 to April 2015）, including 35 patients of the treatment group and 38 patients of the control group. The treatment group was given oral administration of self- prescribed Sanxian soup during the chemotherapy process while the control group was given CapeOX chemotherapy. The patients neurotoxicity symptoms and hand-foot syndrome（HFS） morbidities（grading and distribution）, times and incidences of chemotherapy and chemotherapy completion situation were observed. Results The treatment group was lower than the control group in the morbidities of peripheral nerve toxicity and HFS. Of the 35 patients of the treatment group, 23 patients（65.7%） had nerve toxicity, and of the 38 patients of the control group, 33 patients（86.8%） had nerve toxicity, with statistical difference （P=0.031〈0.05）. After 3 times of chemotherapy, the control group obviously exceeded the treatment group in the morbidity of HFS （P=0,0001 〈0.01）, especially grade I and grade II HFS. Conclusion Self-prescribed Sanxian soup can improve the patient＇s tolerance to chemotherapy and reduce the morbidities of HFS and peripheral nerve toxicity,
出处
《中国现代医生》
2016年第20期125-128,132,共5页
China Modern Doctor
基金
浙江省中医药科学研究基金项目(2015ZB014)
