基于因子分析的张发荣教授治疗甲状腺功能亢进症用药特点研究

Medication Characteristics of ZHANG Farong in Treating Hyperthyroidism

目的:运用因子分析的方法总结和分析张发荣教授临床治疗甲状腺功能亢进症的用药特点。方法:收集自2014年8月—2015年8月间在张发荣教授门诊就诊、有明确疗效的101例甲状腺功能亢进症患者的病历资料和初诊用药处方,录入相应数据库,使用PASW Statistics 18.0统计软件包进行统计分析。结果:101例患者共使用药物98种,用药频次总计1422次,共提取药物组合公因子7个,其方差解释度为86.311%,可涵盖大部分信息。结论:张发荣教授在临床治疗本病初期重视从肝论治,采用疏肝化痰、平肝化痰、调肝化痰;中期在化痰祛瘀的基础上予健脾运湿,益气养阴;后期重视肝肾,多予滋补肝肾,化瘀散结。

Objective： By adopting factor analysis method to summarize and analyze the medication characteristics of Prof. ZHANG Farong in treating hyperthyroidism. Methods： We collect prescriptions of first visit of 101 cases of DPN patients visited Prof. ZHANG Farong from Aug. 2014 to Aug 2015 with clear curative effects. And then gathered the information related to prescriptions of patients and established the database. We conducted the frequency count on medications of patients and filtrated medicine with higher frequency and conducted the factor analysis on them. Results： There were totally97 kinds of medicine in 101 patients. Frequency of medicine was 1422 times in total. Seven factors of drug combinations were extracted. There were some medication characteristics of Prof. ZHANG Farong’s clinical diagnosis and treatment for hyperthyroidism among some common factors of drug combinations by statistical analysis. Conclusion： Prof. ZHANG Farong paid more attention to treatment from liver when treating hyperthyroidism in initial stage by soothing phlegm,calming the liver and eliminating phlegm,regulating liver phlegm. In the middle stage,based on reducing phlegm and blood stasis,strengthening spleen and resolving dampness,supplementing qi and nourishing Yin had been used. In the later stage,he paid more attention to the liver and kidney,nourishing the liver and kidney as well as removing stasis.