α-硫辛酸联合疏血通治疗糖尿病周围神经病变的临床疗效评价

Alpha lipoic Acid Combined with Shuxuetong for Treatment of Diabetic Peripheral Neuropathy

目的:旨在评价α-硫辛酸联合疏血通治疗糖尿病周围神经性病变(DPN)的临床有效性和安全性。方法:选取2014—2015年医院临床确诊为DPN的患者90例,采用随机数字表法分为对照组和治疗组,每组各45例,对照组给予0.9%氯化钠注射液250 m L+α-硫辛酸注射液600 mg静脉滴注,1次/d,疗程为3周。治疗组在此基础上加用疏血通注射液6 m L+生理盐水250 m L静脉滴注,1次/d,疗程同对照组。观察两组患者治疗结束后的临床症状、体征,评价治疗后总有效率,不良反应发生情况,以及治疗前后神经传导速度和波幅的变化。结果:治疗组总有效率为95.56%,明显优于对照组的66.67%,且治疗组的神经传导速度和幅度明显提高,差异均有显著统计学意义(P<0.05),两组均无不良反应发生。结论:α-硫辛酸联合疏血通治疗糖尿病周围神经性病变疗效显著,值得临床推广。

Objective： To evaluate the clinical efficacy and safety of α-lipoic acid combined with Shuxuetong for the treatment of diabetic peripheral neuropathy（ DPN）. Methods： Ninety patients with DPN were selected and randomly divided into control group and treatment group through random number table from 2014 to 2015,45 cases in each group. Control group was given 0. 9% sodium chloride 250 m L ＋ 600 mg of α-lipoic acid by intravenous dripping,once a day. The course of the treatment was 3 weeks. Treatment group were additionally given 6 m L Shuxuetong ＋ 250 m L saline by intravenous dripping on the basis of control group,once a day. And then observe the clinical symptoms and signs at the end of the treatment and evaluate the treatment effect and adverse reactions and compare the nerve conduction velocity and range indexes before and after treatment. Results： The total effective rate of treatment group was 95. 56%,significantly higher than the control group’s（ 66. 67%）. The nerve conduction velocity and range of treatment group were also improved obviously. All of them had the significant difference（ P 〈 0. 05） and both groups had no adverse reaction. Conclusion： The therapeutic effect of α-lipoic acid combined with Shuxuetong for the treatment of diabetic peripheral neuropathy was obvious and worthy of clinical promotion.