黄芪生脉饮联合西医综合治疗小儿反复呼吸道感染的效果及免疫状况分析

Huangqi Shengmai Decoction Combined with Western Medicine Treatment of Children with Recurrent Respiratory Tract Infection and Immune Status

目的:研究黄芪生脉饮联合西医综合治疗小儿反复呼吸道感染的(RRTI)效果及免疫状况并进行分析。方法:选取2012年3月—2015年4月期间,医院收治的120例RRTI患者,采用随机数表法,将120例患者平均分为研究组和对照组,每个组各60例。发作期针对两组患者均采取常规西医治疗,缓解期针对对照组采取转移因子口服液治疗,10 m L/次,每天1次,口服;研究组患者采取黄芪生脉饮治疗,10 m L/次,2次/d,口服。两组患者治疗疗程都为8周,并且对所有患者行6个月的随访。观察记录患者的肺脾气虚证积分,检测治疗前后患者的T细胞亚群以及免疫球蛋白。结果:经治疗后研究组的总有效率高达98.33%,明显的高于对照组的有效率68.33%,并且差异具有统计学意义(χ~2=19.440 0,P=0.000 0);研究组患者治疗后IgG与IgA明显高于对照组,且差异具有统计学意义(P<0.05);研究组患者CD_3^+、CD_4^+、CD_8^+以及CD_4^+/CD_8^+改善程度明显地优于对照组,差异具有统计学意义(P<0.05);研究组患者治疗后各症状积分与肺脾气虚证总积分都显著低于对照组,差异具有统计学意义(P<0.05)。结论:发作期两组患者均采取常规西药治疗,缓解期采取黄芪生脉饮治疗,可显著地改善患儿体质,提高治疗有效率,减轻患儿的临床症状,减少痛疼,值得在临床上推广应用。

Objective： To study the effect of Huangqi Shengmai Decoction combined with integrated traditional Chinese and Western medicine in the treatment of children with recurrent respiratory tract infection（ RRTI） and immune status.Methods： A total of 120 cases of patients with RRTI from March 2012 to April 2015,according to the random number table method,were randomly divided into study group and control group,60 cases in each. In onset period,two groups used the conventional western medicine treatment and in remission the control group took the transferring factor oral liquid,10 ml /time,once a day,orally. Patients in the study group ttook Huangqi Shengmai Decoction,10 m L / time,twice a day,orally. The two groups were treated for 8 weeks and all patients were followed up for 6 months. The T cell subsets and immunoglobulin were observed. Results： After the treatment,the study group’s total efficiency was up to 98. 33%,significantly higher than that of control group’s 68. 33% and the difference was statistically significant（ chi square = 19. 440 0,P = 0. 000 0）. After treatment,the study group’s IgG and IgA were significantly higher than those of control group and the difference had statistical significance（ P 〈 0. 05）. Improvements of CD3＋,CD4＋,CD8＋and CD4＋/ CD8＋in study group were significantly superior to the control group’s and the difference was statistically significant（ P 〈 0. 05）. The study group’s symptom integral and Qi deficiency of lung and spleen total score were significantly lower than those of the control group and the difference was statistically significant（ P 〈 0. 05）. Conclusion： Two groups took conventional western medicine treatment in onset period and in remission stage Huangqi Shengmai Decoction can significantly improve the children physique,the treatment efficiency,relieve the patients’ clinical symptoms,reduce the pain. It is worth in the clinical application.