胃肠癌贫血患者EPO、EPO-R和MVD的相关性研究

Correlation Study between ERO,EPO-R and MVD on Patients with Gastrointestinal Cancer Anemia

目的:探讨胃肠癌贫血患者EPO、EPO-R和微血管密度(MVD)表达的关系。方法:对177例胃肠癌患者进行常规方法检测Hb、血浆EPO浓度,免疫组化法检测EPO、EPO-R、MVD,并进行相关分析。结果:(1)57例贫血患者的EPO水平明显高于无贫血者(P<0.05);血清EPO水平和Hb值呈明显负相关(P<0.001)。(2)EPO、EPO-R阳性患者的MVD明显高于EPO、EPO-R阴性患者(P<0.05);MVD与EPO、EPO-R呈正相关(P<0.001)。结论:胃肠癌贫血患者的EPO水平明显增高,并与Hb值呈明显的负相关关系;EPO、EPO-R的表达与MVD呈正相关。

Objective：To discuss the relationship between EPO,EPO-R and microvascular density （MVD） expression on patients with gastrointestinal cancer anemia.Method：Used conventional methods to detect Hb and serum EPO concentration,EPO,EPO-R and MVD was detected by immunohischemical method for 177 patients with gastrointestinal cancer.Finally correlation analysis was carried on.Result：（1）EPO levels of 57 patients with anemia was obviously higher than that of Hb in without-anemia（P〈0.05）.There was obvious negative correlation between serum EPO level and Hb values（P〈0.001）.（2）MVD of EPO and EPO-R express positive patients was obviously higher than that of negative patients（P〈0.05）. There was obvious positive correlation between EPO and EPO-R and MVD（P〈0.001）.Conclusion：The Epo levels were increased significantly on patients with gastrointestinal cancer anemia and it’s relationship with Hb are significantly negative correlation. The expression of EPO,EPO-R and MVD were positively correlated.