麻醉深度对老年患者术后认知功能的影响

Effect of Depth of Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients

目的：研究不同的麻醉深度的静吸复合麻醉对老年患者术后认知功能（POCD）的影响。方法：选取采用静吸复合麻醉的65岁以上老年患者150例，随机将患者分为L组（术中BIS值维持50～60）、M组（术中BIS值维持40～50）和D组（术中BIS值维持30～40），每组50例。分别在术前1 d、术后3、5 d对患者进行精神状态量表（MMSE）评分，在术前1 d和术后3 d进行痕迹连线测试（TMT）和数字广度测验。对比分析不同时间点的评分差异。结果：L组和D组患者术后三项评分与术前比较差异均有统计学意义（P〈0.05），两组术后评分与M组比较差异均有统计学意义（P＆lt;0.05）。结论：静吸复合全麻麻醉深度对老年患者术后认知功能有影响，术中BIS值维持在40～50时对老年患者术后认知功能影响较小。

Objective： To explore the effect of different depth of anesthesia postoperative cognitive dysfunction in elderly patients.Method： The 150 patients who were over the age of 65, were randomly divided into three groups, each group had 50 cases, group L： 50〈BIS value 〈60, group M： 40〈BIS value〈50, group D： 30〈BIS value〈40.Cognitive function was assessed using the Mini-Mental State Examination （ MMSE ） at 1 d before anesthesia and 3, 5 d after surgery, Cognitive function was assessed using Digit span test and Trail- Making Test （ TMT ） at 1 d before anesthesia and 3 d.Result： Three scores of group L and group D were compared with preoperative, the differences were statistically significant （P〈0.05） .Compared with groups M, MMSE scores, Digit span test and TMT completion time had significant differences in group L and group D （ P〈0.05 ） . Conclusion： Effect of depth of anesthesia on postoperative cognitive function in elderly patients.The intraoperative BIS value was maintained at 40-50, which had little effect on postoperative cognitive function in elderly patients.