高血压合并急性ST段抬高心肌梗死患者介入术后炎症因子的改变分析

Analysis on Changes of Inflammatory Factors in Patients with Hypertension Complicated with Acute ST Segment Elevation Myocardial Infarction after Interventional Operation

目的:观察高血压合并急性ST段抬高心肌梗死患者经皮冠状动脉介入治疗(PCI)术后炎症因子的改变特点。方法:选取2013年1月-2015年6月本院收治的PCI治疗急性ST段抬高心肌梗死患者100例作为研究对象,按照有无合并原发性高血压分为观察组60例和对照组40例。比较两组患者介入术前后人类生长因子(HGF)、超敏C反应蛋白(hs-CRP)及人可溶性CD40配体(SCD40L)水平。结果:治疗前,两组患者HGF、hs-CRP及s CD40L水平比较差异均无统计学意义(P>0.05);治疗后,两组患者HGF较治疗前升高,hs-CRP和s CD40L较治疗前降低,比较差异均有统计学意义(P<0.05);治疗后,观察组HGF低于对照组,hs-CRP和s CD40L高于对照组,比较差异均有统计学意义(P<0.05)。结论:急性ST段抬高心肌梗死患者经PCI治疗后可明显降低血清炎症因子的水平,合并高血压患者的治疗效果比未合并高血压患者要差,合并高血压是急性ST段抬高心肌梗死患者介入治疗的不利因素。

Objective：To observe the changes of inflammatory factors after percutaneous coronary intervention（PCI） in patients with hypertension and acute ST segment elevation myocardial infarction. Method：From January 2013 to 2015 June,100 cases of hypertension and acute ST segment elevation myocardial infarction via PCI treatment in our hospital were selected as the research objects,they were divided into the observation group of 60 cases and the control group of 40 cases according to whether combination of essential hypertension.The levels of human growth factor（HGF）,high sensitive C reactive protein（hs-CRP） and human soluble CD40 ligand（SCD40L） were compared of two groups before and after intervention.Result：Before treatment,there were no significant differences in the levels of HGF,hs-CRP and sCD40L of two groups（P〉0.05）, after treatment,two groups of HGF were higher than those of before treatment,hs-CRP and sCD40L were lower than those of before treatment,the differences were statistically significant（P〈0.05）.After treatment,the observation group HGF was lower than that of the control group,hs-CRP and sCD40L were higher than those of the control group,the differences were statistically significant（P〈0.05）.Conclusion：Acute ST segment elevation myocardial infarction patients after PCI treatment can significantly reduce the level of serum inflammatory factors, the treatment effect of patients with hypertension is worse than patients without hypertension,and hypertension is an unfavorable factor for interventional therapy in patients with acute ST segment elevation myocardial infarction.