肿瘤恶病质与白色脂肪组织棕色化

Cancer cachexia and white adipose tissue browning

晚期肿瘤患者多伴有恶病质的发生，这些患者身体功能减退，对抗肿瘤治疗的耐受力变差，存活率明显下降。目前临床上用于治疗肿瘤恶病质的手段十分有限，深入了解肿瘤恶病质发生、发展的分子机制，并从新的角度探索有效治疗手段是必要而迫切的。最新的研究表明，白色脂肪组织棕色化是肿瘤恶病质一项重要的特征，白色脂肪组织的这种转变导致脂肪动员增加，并使机体能量过度消耗，这可能是肿瘤恶病质发生、发展的重要原因之一。文章主要对肿瘤恶病质和白色脂肪组织棕色化的定义及特点进行了概述，并结合相关研究的最新进展，探讨了肿瘤恶病质研究的新方向。

Cancer cachexia occurs in a majority of advanced cancer patients. These patients with impaired physical function are unable to tolerance cancer treatment well and have a significantly reduced survival rate. Currently, there is no effective clinical treatment available for cancer cachexia, therefore, it is necessary to clarify the molecular mechanisms of cancer eachexia, moreover, new therapeutic targets for cancer cachexia treatment are urgently needed. Very recent studies suggest that, during cancer cachexia, white adipose tissue undergo a ‘browning＇ process, resulting in increased lipid mobilization and energy expenditure, which may be necessary for the occurrence of cancer eachexia. In this article, we summarize the definition and characteristics of cancer caehexia and adipose tissue ‘browning＇ , then, we discuss the new study directions presented in latest research.