摘要
人细小病毒B19（简称B19病毒）与多种自身免疫性疾病关系密切，这主要缘于其病毒衣壳蛋白。 B19病毒VP1独特区蛋白延伸到病毒衣壳外，有磷脂酶A2位点，含有多个抗原决定簇，可刺激宿主产生自身抗体，诱发和/或加重多种自身免疫性疾病。结合文献和本课题组工作，本文对B19病毒VP1独特区蛋白的生物学特性及其与自身免疫性疾病的关系进行综述，这有助于B19病毒感染的预防和治疗。
Human parvovirus B19, generally referred to as B19 virus, has been closely associated with a variety of different autoimmune diseases due to the features of its capsid protein. B19 virus VP1 unique region protein that has sites of phospholipase A2 and several antigenic determinants is exposed on the outside of the viral capsid protein. As a result of that, B19 virus VP1 unique region protein can stimulate the host to produce autoantibodies, which induces and/or aggravates the autoimmune diseases. The biological characteristics of B19 virus VP1 unique region protein and its relationships with autoimmune diseases are de-scribed in this review based upon the published literatures and the work achieved by our research team. This review will be helpful to the prevention and treatment of B19 virus infection.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2016年第7期545-548,共4页
Chinese Journal of Microbiology and Immunology
基金
国家自然科学基金资助项目（81300583）
福建省自然科学基金资助项目（2014J05096）
中国博士后科学基金资助项目（2014M552705）
2013-2014年福建高层次人才访学研修资助项目（闽人办201376号）
