肝癌的代谢类和受体类核医学显像剂研究进展

Research progress in metabolic and receptor-like nuclear imaging agents for hepatocellular carcinoma

肝癌发病率和死亡率高，早期分期诊断及治疗是延长生存期的关键。相比较于超声、X线计算机断层摄影术、磁共振成像等传统形态学检查手段，基于各种放射性核素标记的分子探针在分子水平上进行功能显像的单光子发射计算机断层显像、正电子发射计算机断层显像，在肝癌的早期诊断、疗效判断、预后评估及治疗计划的拟定等方面日益显现出重要的价值。

Hepatocellular carcinoma （HCC） commonly presents with high morbidity and mortality, and early staging diagnosis and timely treatment is pivotal to prolonging patients＇ survival time. Compared with traditional morphological imaging methods such as ultrasound, computed tomography （CT）, and magnetic resonance imaging （MRI）, functional imaging methods like single-photon emission computed tomography （SPECT） and positron emission tomography （PET） are playing an increasingly important role in the early diagnosis, efficacy assessment, prognostic evaluation, and treatment planning for HCC, thanks to their higher sensitivity at a molecular level by using various radiopharmaceuticals.