盐酸米诺环素复合明胶海绵预防干槽症的临床研究

Clinic study of minocycline hydrochloride combined with gelatin sponge in prevention of dry socket

目的：观察盐酸米诺环素明胶海绵在预防干槽症中的作用。方法选择2015年5月～12月我院收治的拔出下颌阻生智齿的120例患者，随机将其分为观察组与对照组，各60例，观察组拔牙后在牙槽窝中置入盐酸米诺环素明胶海绵，对照组牙拔除术后牙槽窝内不放置任何充填物，常规口服抗生素3天。结果观察组发生干槽症1例，发生率为1.67%，对照组发生干槽症5例，发生率为8.33%。两组比较，差异有统计学意义（P＜0.05）。结论盐酸米诺环素明胶海绵能有效地预防下颌阻生智齿拔牙术后干槽症的发生。

Objective To observe clinic effect minocycline hydrochloride combined with gelatin sponge in the prevention of dry socket.Methods 120 case of impacted mandibular third molars extracted were divided into two group at random equally. One was the experimental group, in which we implanted minocycline hydrochloride combined with gelatin sponge into teeth alveolar fossa; the other was contrast group, in which we didn’t implant anything into teeth alveolar fossa The contrast group received administration of antibiotics for three days.Results Hydrochloride minocycline hydrochloride gelatin sponge group, the incidence of dry socket in 1 cases. The incidence rate of 1.67%. In the control group, the incidence of dry socket 5 cases occurred rate was 8.33%. Statistically significant differences between the two groups （P〈0.05）. Conclusion Minocycline hydrochloride gelatin sponge can effectively prevent the occurrence of dry socket after extraction of mandibular impacted teeth.