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人巨细胞病毒微小RNA对病毒潜伏状态的影响

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摘要 人巨细胞病毒（human cytomegalovirus，HCMV）可编码多种成熟微小RNA（microRNA，miRNA）以调节自身及宿主基因表达，影响病毒复制并参与多种免疫逃逸机制，对于实现病毒的终生潜伏感染十分重要。我国HCMV感染率较高，孕妇血清IgG抗体阳性率达95％以上，母体原发感染或潜伏感染激活均可引起HCMV宫内感染，导致流产、死胎、胎儿畸形及生长发育迟缓。
作者 卢元元 方峰
机构地区 华中科技大学同济医学院附属同济医院儿科
出处 《中华儿科杂志》 CAS CSCD 北大核心 2016年第8期632-634,共3页 Chinese Journal of Pediatrics
基金 国家自然科学基金（81271807）
关键词 人巨细胞病毒 微小RNA 潜伏状态 HCMV感染率 免疫逃逸机制 生长发育迟缓 潜伏感染 抗体阳性率
分类号 R725.1 [医药卫生—儿科]
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参考文献29

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中华儿科杂志
2016年 第8期

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