高压氧联合神经节苷脂对脑出血患者凝血酶、血清髓鞘碱性蛋白、D-二聚体的影响

Effect of hyperbaric oxygen combined with ganglion glycosides on thrombin,serum myelin basic protein and D-dimer in patients with intracerebral hemorrhage

目的观察高压氧联合神经节苷脂对脑出血患者凝血酶、血清髓鞘碱性蛋白、D-二聚体的影响。方法选取2014年6月—-2015年6月西安交通大学第一附属医院神经外科收治的脑出血患者100例为研究对象,按入院顺序随机分为对照组和观察组各50例,在常规治疗基础上对照组给予神经节苷脂治疗,观察组给予高压氧联合神经节苷脂治疗。观察治疗前后凝血酶、血清髓鞘碱性蛋白、D-二聚体、血肿体积、神经功能缺损评分（NIHSS）、日常生活能力评分（ADL）变化,并评价临床疗效。结果治疗前2组凝血酶、血清髓鞘碱性蛋白、D-二聚体、血肿体积、NIHSS及ADL评分比较差异均无统计学意义（P〉0.05）,治疗后2组凝血酶、血清髓鞘碱性蛋白、D-二聚体、血肿体积、NIHSS评分较治疗前均显著下降（P〈0.05）,ADL评分较治疗前均显著升高（P〈0.05）,且观察组较对照组上述指标改善更为明显（P〈0.05）。对照组治疗痊愈率、显著进步率、进步率分别为24.00%、36.00%、24.00%,观察组分别为30.00%、40.00%、24.00%,观察组总有效率显著优于对照组（94.00%vs.84.00%,χ^2=3.55,P〈0.05）。结论高压氧联合神经节苷脂可降低脑出血患者凝血酶、血清髓鞘碱性蛋白、D-二聚体水平,提高治疗疗效。

Objective To observe the effect of hyperbaric oxygen combined with ganglion glycosides on thrombin, se-rum myelin basic protein and D-dimer in patients with intracerebral hemorrhage.Methods Selected from June 2014 to June 2015, 100 cases of cerebral hemorrhage patients in Xi＇an Jiaotong University First Affiliated Hospital neurosurgery department as the research object, according to the order of admission, they were randomly divided into control group and observation group, each group of 50 cases, on the basis of conventional therapy patients in control group were treated with ganglioside treatment, the observation group given hyperbaric oxygen combined with ganglioside treatment.Before and after treatment, thrombin, serum myelin basic protein, D-dimer, hematoma volume, neurological function defect score （ NIHSS） , daily life a-bility score （ ADL） were observed, and the clinical effect was evaluated.Results Before treatment, 2 groups of thrombin, serum myelin basic protein （ MBP） , D-dimer, volume of hematoma, NIHSS and ADL score differences had no statistical sig-nificance （ P 〉0.05）, after treatment, two groups of thrombin, serum myelin basic protein （MBP）, D-dimer, hematoma volume and NIHSS score compared with those before treatment were significantly decreased （ P 〈0.05）, ADL score before treatment were significantly higher （ P 〈0.05） , and the observation group was more obvious than that of the control group, the above indicators improved （ P 〈0.05）.The control group cured rate, significant progress rate, improvement rate were 24.00%, 36.00%, 24.00%, the observation group were 30.00%and 40.00%, 24.00%observed group, the total efficien-cy is remarkably higher than that of the control group （94.00%vs.84.00%,χ^2 =3.55, P 〈0.05）.Conclusion Hyperbaric oxygen combined with ganglion glycosides can reduce the level of thrombin, serum myelin basic protein and D-dimer levels in patients with cerebral hemorrhage,and improve the therapeutic effect.