双歧杆菌四联活菌片辅助治疗小儿非感染性腹泻疗效及其对血清IL-6、IL-17水平的影响

The therapeutic effect of bifidobacterium tetravaccine tablets in the adjunctive treatment of children's noninfectious diarrhea and its influence on the levels of serum IL-6 and IL-17

目的观察双歧杆菌四联活菌片(思连康)辅助治疗小儿非感染性腹泻的效果及其对血清IL-6、IL-17水平的影响。方法选取2014年3月—2015年2月陕西省榆林市中医医院儿科治疗的非感染性腹泻患儿68例,按照抽签法随机分为观察组和对照组各34例。对照组给予常规治疗,观察组在此基础上加用思连康。比较2组总有效率,治疗前和治疗7 d后IL-6、IL-17水平,并对2组患儿治疗后的病情改善情况进行比较。结果观察组总有效率为91.18%(31/34),明显高于对照组的70.59%(24/34),差异有统计学意义(P<0.05);治疗后,观察组血清IL-6、IL-17水平明显低于对照组[(9.47±1.01)pg/ml vs.(16.08±3.11)pg/ml,(10.47±1.14)pg/ml vs.(17.85±3.44)pg/ml,P<0.05];患儿体温恢复至正常时间、腹泻停止时间、住院时间均明显短于对照组[(3.11±0.63)d vs.(6.04±1.02)d,(2.21±0.31)d vs.(4.24±0.63)d,(4.22±0.54)d vs.(7.32±1.02)d,P<0.05]。结论小儿非感染性腹泻采取思连康进行治疗,可提高临床疗效,能明显降低患儿血清IL-6、IL-17水平,缩短止泻时间和治疗时间,明显改善病情。

Objective To study the therapeutic effect of bifidobaeterium tetravaccine tablets （intestinal probiotics） in the treatment of children’ s noninfectious diarrhea and its influence on the levels of serum IL-6 and IL-17.Methods From March 2014 to February 2014, 68 cases of noninfectious diarrhea in Yulin, Shanxi,traditional Chinese medicine hospital were enrolled, according to the draw method, they were divided into observation group and control group, 34 cases in each group. Control group was treated with conventional treatment, while the observation group was treated with intestinal probiotics on the basis of control group.Total effect, IL-6, IL-17 levels before and after treatment of 7 d were compared, and the improvements of pathogenetic conditions after treatment of two groups patients were observed.Results The total clinical efficacy rate of ob-servation group was 91.18%（31/34）, which was significantly higher than the control group of 70.59%（24/34）, statistical-ly significant difference （ P 〈0.05） .After treatment, the serum levels of IL-6, IL-17 in observation group were obviously lower than the control group [（9.47 ±1.01） pg/ml vs.（16.08 ±3.11） pg/ml,（10.47 ±1.14） pg/ml vs.（17.85 ±3.44） pg/ml, P 〈0.05], the differences were statistically significant （ P 〈0.05）.Observation group of the patient＇s body temper-ature returned to normal time, diarrhea stop time, hospital stay were all obviously shorter than those of the control group [（3.11 ±0.63） d vs.（6.04 ±1.02）d , （2.21 ±0.31） d vs.（4.24 ±0.63）d , （4.22 ±0.54） d vs.（7.32 ±1.02）d, P 〈0.05].Conclusion Pediatric infectious diarrhoea taking intestinal probiotics treatment can improve the total effect, sig-nificantly reduce serum level of IL-6, IL-17 and shorten the antidiarrheal time and treatment time, and its clinical curative effect is obviously.