女性泌尿生殖道分泌物支原体感染及药敏分析

目的了解女性非淋菌性尿道炎（NGU）患者解脲脲原体（uu）、人型支原体（Mh）感染的现状、分布及耐药情况，指导临床合理用药。方法对950例女性非淋菌性尿道炎（NGU）患者按照支原体培养试剂盒说明进行标本采集和检测及药敏分析。结果950例NGU患者中．支原体感染阳性患者494例（52％），494例支原体阳性患者中单纯uu阳性患者322例（33．9％），单纯Mh阳性患者13例（1．4％），Uu＋Mhg阳性患者159例（16．7％）。494例支原体阳性患者药敏试验结果：环丙沙星〉92.2％，耐药率最高；氧氟沙星〉75．2％；红霉素〉69．8％；四环素〉68．5％。对交沙霉素、强力霉素、原始霉素较为敏感（敏感率〉94．2％）。494例支原体阳性患者中，有8例患者对药敏全耐药，且这8例患者均为Uu＋Mh混合感染，Uu＋Mh混合感染检出率逐年上升，对环丙沙星、氧氟沙星、红霉素耐药率高。单纯的Uu阳性患者对克拉霉素（敏感率〉77，2％）、阿奇霉素（敏感率〉69．5％）较为敏感，单纯Mh阳性患者及Uu＋Mh阳性患者对克拉霉素、阿奇霉素耐药率较高（耐药率均〉68．5％）。结论NGU患者感染以支原体感染为主，解脲支原体感染占多数。临床分离培养所得的支原体药敏大部分具有多重耐药性及高耐药性。临床应根据药敏结果合理选用抗生素，提高治愈率及防治复发。

Objective To understand the female non gonococcal urethritis （ NGU ） Ureaplasma urealyticum （ Uu ） , type mycoplasma （ Mh ） infection status, distribution and drug resistance, so as to guide the rational use of drugs in the clinic. Method The 950 cases of female non gonococcal urethritis （ NGU ） patients in accordance with the mycoplasma culture kit instructions for specimen collection and detection and drug sensitivity analysis.Result Of the 950 patients with NGU, 494 （ 52% ） were mycoplasma infection positive patients, 494 （ 33.9% ） of Uu positive patients, 13 （ 1.4% ） of Mh positive patients, 159 （ 16.7% ） of Uu^Mh positive patients. Results Of drug sensitivity test of 494 cases of Mycoplasma positive patients：Ciprofloxacin resistance rate was 〉92.2%, and the resistance rate was the highest;levofloxacin resistance rate was 〉75.2%;erythromycin resistance rate was 〉69.8%; tetracycline resistance rate was 〉68.5%, It was more sensitive to josamycin, doxycycline, original mold （ sensitive rate 〉94.2% ） .494 cases of Mycoplasma positive patients, 8 cases of patients with drug resistance, and these 8 cases were Uu^Mh mixed infection, Uu＋Mh mixed infection rate increased year by year, the high resistance rate of ciprofloxacin, levofloxacin, erythromycin.Simple Uu positive patients weremore sensitive to clarithromycin （ sensitive rate was 〉77.2% ） , azithromycin （ sensitive rate was 〉69.5% ） , simple Mh positive patients and Uu＋Mh positive patients resistant to clarithromycin and azithromycin rate high, resistance rates were 〉68.5% ） . Conclusion NGU patients infected with mycoplasma infection, the majority of Ureaplasma urealyticum infection.The drug sensitivity of Mycoplasma from clinical isolates has multiple drug resistance and drug resistance, according to drug sensitivity, antibiotics should be used rationally to improve the cure rate and prevent recurrence.