T2*值评价健康成年人脑铁含量及其与性别的相关性研究

Study of gender-related iron deposition in brain using T2* value

目的 采用3.0T磁敏感加权成像定量测量健康成年人额叶白质区及灰质核团的T2＊值,探讨灰质核团与性别的相关性。方法 选取年龄25~85岁的128例年龄相匹配的男性组及女性组进行磁共振成像（MRI）常规及磁敏感加权成像（SWI）扫描,经后处理在T2＊图像上分别测量左右侧额叶白质区、红核、黑质网状带、黑质致密带、尾状核头、壳核、苍白球和丘脑的T2＊值,分析T2＊值与性别的相关性。结果 男、女性组左、右侧的T2＊值在苍白球最低,其次为黑质网状带、红核,额叶白质区的最高。男性组右侧黑质网状带、黑质致密带T2＊值小于左侧,女性组右侧黑质网状带T2＊值小于左侧（P0.05）。结论 健康成年人的壳核、丘脑的脑铁含量与性别具有相关性。

Objective To quantitatively analyze the iron deposition in deep brain gray nuclei and frontal white matter in healthy population and its correlation with gender using susceptibility-weighted imaging （SWI） with 3.0 Tesla scanner. Methods A total of 128 healthy subjects （64 males and 64 females, aged 25 to 85 years） were scanned with routine sequences and SWI sequences by 3.0T MR. T2＊ value was measured in left and right frontal white matter, red nucleus, substantia nigra pars reticulata, substantia nigra pars compacta, globus pallidus, putamen, head of caudate nucleus and thalamus; the correlations between the T2＊ value and gender were analyzed. Results The T2＊ value was the lowest in the globus pallidus, followed by substantia nigra reticulata and red nuclei. The highest T2＊ value was seen in the frontal white matter. The T2＊ value of the right substantia nigra compacta and substantia nigra pars reticulata was lower than that of the left-side one in the males （P 〈 0.05）, and the T2＊ value of the right substantia nigra pars reticulate was lower than that of the left-side one in the females （P 〈 0.05）. The T2＊ value of putamen and thalamus was significantly different between the males and the females （P〈 0.05）. Conclusions Using T2＊ value, a significant correlation has been found between putamen and thalamus iron deposition and gender in health population.