支原体感染性肺炎肺泡灌洗液中内脂素的检测及意义

Visfatin in bronchoalveolar lavage fluid(BALF) of children suffering from Mycoplasma pneumoniae with lobar change and its clinical significance

目的:检测支原体肺炎肺泡灌洗液(BALF)中内脂素水平,研究其与BALF中支原体-DNA(MP-DNA)水平的相关性,探讨其临床意义。方法:选取支原体肺炎并行支气管肺泡灌洗术(BAL)的患儿30例,收取肺泡灌洗液,行细胞学检查,并检测BALF中内脂素水平。结果:BALF中内脂素水平与MP-DNA相关(r=0.589,P=0.001);BALF中内脂素水平与淋巴细胞百分比相关(r=0.553,P=0.002)。结论:支原体感染时淋巴细胞介导内脂素参与炎症过程,BALF中内脂素水平与局部MP-DNA滴度相关。

Objective： Visfatin in bronchoalveolar lavage fluid（BALF） of children suffering from Mycoplasma pneumoniae with lobar change and its clinical significance.Methods：30 children suffering from Mycoplasma pneumoniae with lobar change who had been done BALwere selected to be object of study.ELISA method was used to detect level of visfatin.Results：Visfatin expressed in BALF on different levels,the Visfatin in labor mycoplasma pneumoniae is related with copies of MP-DNA（r=0.589,P=0.001）,Visfatinis is related with LY%, too（r=0.553,P=0.002）.Conclusions：In Mycoplasma pneumoniae infections,Lymphocyte and Visfatin plays some role in labor Mycoplasma pneumoniae infection,Visfatin levels in BALF were associated with MP-DNA copies.