四磨汤不同提取部位对小鼠胃肠运动的影响

Effect of Different Extracts of Simotang on Gastrointestinal Movement of Mice

目的探讨四磨汤不同提取部位对不同机能状态下小鼠胃肠运动的影响。方法将四磨汤不同提取部位样品分别对正常、肠亢进及肠抑制小鼠口服灌胃,测量小鼠小肠全长及半固体糊状物在小肠中的推进距离,并计算小肠推进率。结果四磨汤水提醇沉液低、中、高剂量组,醇提液和水洗物中、高剂量组小鼠的对正常小鼠的胃肠运动具有显著促进作用(P<0.05);水提醇沉液,醇提液,水洗物的低、中、高剂量组对肠抑制模型小鼠的肠推进有显著促进作用(P<0.05);水提醇沉液,醇提液,醇洗物的低、中、高剂量组对肠亢进模型小鼠的肠推进有显著抑制作用(P<0.05)。结论四磨汤具有明显的促进胃排空作用,并对小肠运动具有双向调节作用,四磨汤水洗物和醇洗物可能分别是四磨汤促进和抑制小鼠肠运动的有效部位。

Objective To investigate the effects of the different extracts of Simotang on gastrointestinal movement of mice in different state. Methods The mice in different states were given different extracts of Simotang by oral lavage. The total length of the small in- testine of mice and pushing distance of paste were measured, and the rate of intestinal propulsive was then calculated. Results The all dose of water extracting and alcohol precipitation liquids, the medium and high dose of ethanol extract liquids and water extract can promote gastrointestinal motility of normal mice significantly（P 〈 0. 05）; the all dose of water extracting and alcohol precipitation liq- uids, ethanol extract liquids and water extract can enhance intestinal motility of intestinal inhibition mice significantly（P 〈 0. 05）; the all dose of water extracting and alcohol precipitation liquids, ethanol extract liquids and 95% ethanol extract can reduced intestinal motility of intestinal hyperactivity mice significantly（P 〈 0. 05）. Conclusion Simotang has obvious effect on gastric emptying promotion, and has two- way adjustment on intestinal motion. The water extract and the ethanol extract maybe the valid parts of Simotang in promoting and inhibiting intestinal movement of mice .