枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停疗效分析

Effect of caffeine citrate and aminophylline on primary apnea of prematurity

目的探讨枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停(apnea of prematurity,AOP)的有效性及安全性。方法 AOP患儿80例随机分为2组,观察组40例给予枸橼酸咖啡因治疗,对照组40例给予氨茶碱治疗。比较2组治疗有效率及不良反应发生情况。结果观察组治疗有效率(82.5%)与对照组(70.0%)比较差异无统计学意义(P>0.05);观察组心动过速(5.0%)、喂养不耐受(10.0%)、高血糖(7.5%)及支气管肺发育不良发生率(5.0%)低于对照组(22.5%、27.5%、25.0%、20.0%)(P<0.05),早产儿视网膜病变发生率(5.0%)与对照组(7.5%)比较差异无统计学意义(P>0.05)。结论枸橼酸咖啡因治疗AOP疗效与氨茶碱相似,但不良反应发生率较低。

Objective To investigate the clinical effect and safety of caffeine citrate and aminophylline in the treatment of primary apnea of prematurity （AOP）. Methods Eighty infants with AOP were divided into observation group receiving caffeine, and control group receiving aminophylline, with 40 infants in each group. The overall response rates and adverse reaction rates were compared between two groups. Results There was no significant difference in the overall response rate between observation group （82. 5%） and control group （70. 0%） （P〈0.05）. The incidences of tachycardia （5.0%）, feeding intolerance （10. 0%）, high blood glucose （7. 5%） and bronchopulmonary dysplasia （5. 0%） in observation group were significantly lower than those in control group （22.5%, 27.5%, 25.0%, 20.0%） （P〈0.05）. The incidence of retinopathy of prematurity was lower in observation group （5.0%） than that in control group （7.5%）, showing no significant difference between two groups （P〈0.05）. Conclusion Caffeine citrate has similar effect with aminophylline on primary AOP, with lower incidence of adverse reactions.