补肾疏肝方改善绝经综合征情绪障碍的临床研究

The Clinical Research of Bushen Shugan Recipe on Improving the Anxiety and Depression of Patients with Menopausal Syndrome

目的研究自拟补肾疏肝方配合中医情志疗法对于肾虚肝郁证绝经综合征患者抑郁及焦虑症状的疗效。方法将绝经综合征患者属肾虚肝郁证并伴抑郁或焦虑症状者60例随机分为中医治疗组和西医对照组,每组30例。中医治疗组给予自拟补肾疏肝方配合中医情志疗法;对照组给予西药利维爱片。治疗疗程均为8周,随访4周。在初诊、治疗第8周及随访第4周各时点分别填写改良Kupperman评分量表(KI)、抑郁自评量表(SDS)以及焦虑自评量表(SAS)。结果组内治疗第8周与初诊比较,KI评分、SDS标准分及SAS标准分在治疗组及对照组均下降,差异有显著性(P<0.05)。治疗组KI量表评分随访时较第8周时略有升高,二者比较差异无显著性(P>0.05);SDS及SAS标准分较第8周时略有下降,二者比较差异无显著性(P>0.05)。对照组随访时KI量表评分、SDS及SAS标准分均较第8周时升高,且二者比较差异有显著性差异(P<0.05)。结论自拟补肾疏肝方配合中医情志疗法可显著改善肾虚肝郁证绝经综合征患者的焦虑及抑郁症状,且治疗效应持续,不易反弹。

Objectives This study aims to investigate the effect of combined therapy of Chinese herbal medicine Bushen Shugan recipe with emotional therapy on the anxiety and depression in patients with menopausal syndrome. Methods A total of 60 menopausal syndrome patients with symptoms of anxiety or depression were recruited and randomly assigned into Chinese medicine group and Western medicine control group,and each group had 30 cases. Patients in Chinese medicine group were treated with self-made Chinese herbal medicine Bushen Shugan recipe,together with emotional therapy. Patients in the control group were given Tibolone. The patients in both groups were treated for 8 weeks,and followed up for 4 weeks. At the first visit,the eighth weeks after treatment and the fourth weeks of following up,the modified Kupperman Rating Scale（ KI）,self rating Depression Scale（ SDS） and self rating Anxiety Scale（ SAS） were completed. Results The scores in KMI index,SDS index,and SAS index were significantly lower after treatment in both Chinese medicine group and control group,and the difference was significant（ P〈0. 05）. However,scores in KMI index,SDS index,and SAS index in Chinese medicine group were not significantly different at baseline,4^（th）week,8^（th）week and the end of following-up when compared with those in the control group,and there was no significant difference（ P〈0. 05）. During the period of following-up,scores in KMI index,SDS index,and SAS index in Chinese medicine group decreased consistently. However,scores in KMI index,SDS index,and SAS index in the control group exhibited a litter elevation. Conclusions The Bushen Shugan recipe with emotional therapy can significantly attenuate anxiety and depression in patients with menopausal syndrome,the therapeutic effect continues,and is not easy to relapse.