云南白药配合湿润烧伤膏在鼻中隔黏膜溃疡中的疗效观察

The efficacy of Yunnan Baiyao with MEBO in the nasal septum ulcers

目的研究云南白药配合湿润烧伤膏治疗鼻中隔黏膜溃疡的临床疗效。方法选择2014年8月1日至2016年2月29日我院收治的143例鼻中隔黏膜溃疡患者,按治疗方法分为三组:湿润烧伤膏组42例(采用湿润烧伤膏治疗);云南白药组46例(采用云南白药膏治疗);联合用药组55例(采用湿润烧伤膏联合云南白药粉治疗)。对比三组临床疗效、止血、复发情况及VAS疼痛评分。结果联合用药组总有效率为96.4%,高于云南白药组的84.8%和湿润烧伤膏组的85.7%,差异具有统计学意义(P<0.01);联合用药组1疗程止血率为81.8%,复发率为5.5%,分别优于云南白药组的73.9%、17.4%和湿润烧伤膏组的73.8%、16.7%;治疗3 d后联合用药组VAS评分为(2.65±0.75)分,低于云南白药组的(3.78±0.82)分和湿润烧伤膏组的(3.91±0.88)分,差异具有统计学意义(P<0.01)。结论云南白药配合湿润烧伤膏治疗鼻中隔黏膜溃疡,具有疗效显著、止血迅速、缓解疼痛明显等优点,值得临床推广。

Objective To investigate the clinical efficacy of Yunnan Baiyao with moist burn ointment （MEBO） in treat- ment of nasal mucosal ulceration. Methods From August 1, 2014 to February 29, 2016 in our hospital, 143 cases of pa- tients with nasal septum ulcers were selected and divided into three groups according to their treatment： 42 cases were classified to MEBO group （MEBO therapy）; 46 cases were classified to Yunnan Baiyao group （ Yunnanbaiyao cream thera- py）; 55 cases were classified to combined treatment group （MEBO 1-2 g and 0.5-1 g powder mixed Yunnan Baiyao after applying the gelatin sponge or Vaseline gauze packing or ulcers then spreads into the nasal cavity）. The bleeding and re- currence, and VAS pain score of patients in three groups were compared. Results The total effective rate of combined treat- ment group was 96.4%, higher than Yunnan Baiyao Group （84.8%） and MEBO group （85.7%）, the difference was statisti- cally significant （P〈0.01）; the hemostasis of 1 course was 81.8%, and the recurrence was 5.5% in the combined treatment group, which were better than Yunnan Baiyao Group （73.9%,17.4%） and MEBO group（73.8%,16.7%）; 3 d after treatment VAS score of the combined treatment group was （2.65±0.75）, which were lower than Yunnan Baiyao group （3.78±0.82） and MEBO group （3.91±0.88） （P〈0.01）. Conclusion Yunnan Baiyao with MEBO in treating nasal septum ulcers have significant effect, like stoping the bleeding quickly, relieving pain, etc, and is worthy for promotion.