呼吸暂停综合征对胰岛素样生长因子-1与心泵功能的关联分析

Association between insulin-like growth factor 1 and its heart pump function in patients with obstructive sleep apnea syndrome

目的分析阻塞性睡眠呼吸暂停综合征(OSAS)对胰岛素样生长因子-1(IGF-1)及心脏功能的影响,并探讨OSAS患者IGF-1与心脏功能的相关性。方法应用分层抽样法,分别就诊于我院的健康体检者及OSAS患者中,随机选取80例健康体检者及80例OSAS患者为观察对象。以选取的健康体检者为对照组,以选取的OSAS患者作为观察组。对比两组间血清IGF-1含量、右房内径(RA)、左房内径(LAD)、右室内径(RV)、左室舒张末内径(LVED)及左室射血分数(LVEF)差异。并分析IGF-1与RA、LAD、RV、LVED及LVEF相关性。结果观察组IGF-1含量、RV、LVED及LVEF明显低于对照组(P<0.05)。观察组RA、LAD明显高于对照组(P<0.05)。观察组中重度组IGF-1含量、RV、LVED及LVEF最低,RA、LAD最高(P<0.05)。IGF-1含量与RV、LVED及LVEF存在正向直线相关性,与RA、LAD存在负向直线相关性(P<0.05)。结论 OSAS可显著影响患者的IGF-1及心脏功能,且IGF-1与心脏功能间存在显著的相关性。

Objective To analyze the association between insulin-like growth factor 1 and its heart pump function in patients with obstructive sleep apnea syndrome .Methods 80 healthy people were taken as the control group, and another 80 patients with OSAS were selected as the observation group .Comparison content of serum IGF-1, the right diameter（RA）, left atrial diameter（LAD）, right ventricular（RV） , left ventricular end-diastolic diame-ter（LVED） and left ventricular ejection fraction （LVEF）.The levels of IGF-1, RA, LAD, RV, LVED and LVEF were recorded and compared between the two groups .Results The value of RV , LVED, IGF-1 and LVEF of the ob-servation group were significantly lower than that of the control group （P〈0.05）.The value of RA and LAD of the observation group was obviously higher than that of the control group （P〈0.05）.In the observation group, the level of IGF-1, RV, LVED and LVEF were the lowest, and the value of RA and LAD was the highest （P〈0.05）.IGF-1 content showed a positive linear correlation with RV , LVED and LVEF, and a negative linear correlation with RA and LAD （P〈0.05）.Conclusion Patients with OSAS can significantly influence the IGF-1 and cardiac function, and IGF-1 has significant correlation with heart function .