女性焦虑障碍对供精体外受精-胚胎移植妊娠结局的影响

The Influence of Anxiety Disorder of Infertile Women on the Pregnancy Outcome of In-vitro Fertilization –embryo Transfer with Donor Semen

目的探讨焦虑障碍对不孕女性接受供精体外受精-胚胎移植(IVF-D/ICSI-D)后妊娠结局的影响。方法采用汉密尔顿焦虑量表(HAMA)对70例行IVF-D/ICSI-D治疗的不孕女性进行焦虑程度测评,并根据焦虑程度分为A、B两组,A组40例,轻度或中度焦虑;B组30例,重度焦虑。比较两组取卵数、受精率、优胚率、胚胎种植率、临床妊娠率及早期流产率等。结果两组比较,取卵数、优胚率、临床妊娠率均随着焦虑程度的加剧而降低,差异有统计学意义(P<0.05)。结论焦虑障碍可对IVF-D/ICSI-D产生不良影响,应把握患者的焦虑程度,进行恰当的心理干预及治疗以改善妊娠结局。

Objective To explore the influence anxiety disorder of infertile women on the clinic pregnancy outcome of in-vitro fertilization–embryo transfer with donor semen（IVF-D/ICSI-D）. Methods Hamilton Anxiety Scale（HAMA） was adapted to evaluated the degree of anxiety of 70 women undergoing IVF-D/ICSI-D, all cases were divided into two groups： A group included 40 cases with mild or moderate anxiety, B group included 30 cases with severe anxiety. Several key parameters of the two groups, included the number of retrieved oocyte , fertility rates, high qualified embryo rates, embryo implantation rates , clinical pregnant rates and early abortion rates were compared and analyzed. Results The retrieved oocyte number, high qualified embryo rates, clinical pregnant rates were significantly reduced with the increase of anxiety degree （P〈0.05）. Conclusion Anxiety disorder has a negative impact on clinic pregnancy of IVF-D/ICSI-D. We should grasp and undstand the anxiety degree and carry through measurable mental invention to improve the pregnancy outcome.