1Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of the GINA Dissemination Committee report [J]. Allergy, 2004, 59(5):469-478.
2Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma[ J]. N Engl J Med, 2011, 364 ( 8 ) :701-709.
3Berro AI, Perry GA, Agrawal DK. Increased expression and activation of CD30 induce apoptosis in human blood eosinophils [J]. J Immunol, 2004, 173 (3) :2174-2183.
4Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways[J]. PLoS One, 2010, 5 ( 1 ) : e8578.
5Charlson ES, Bittinger K, Haas AR, et al. Topographical continuity of bacterial populations in the healthy human respiratory tract[J]. Am J Respir Crit Care Med, 2011, 184(8) :957-963.
7Berry M, Morgan A, Shaw DE, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma[J]. Thorax, 2007, 62(12) :1043-1049.
4Djukanovic R, Homeyard S, Gratziou C, et al. The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation. Am J Respir Crit Care Med,1997,155:826-832.
5Oda N, Canelos PB, Essayan DM, et al. Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response. Am J Respir Crit Care Med,2005,171:12-18.
6Molet S, Hamid Q, Davoine F, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol, 2001,108:430-438.
7Barczyk A, Pierzchala W, Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med,2003,97:726-733.
8Chakir J,Shannon J, Molet S, et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type Ⅰ and type Ⅲ collagen expression. J Allergy Clin Immunol, 2003,111:1293-1298.
9Cundall M, Sun Y, Miranda C, et al. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J Allergy Clin Immunol, 2003,112:1064-1071.
10Wenzel SE, Szefler SJ, Leung DY, et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med,1997,156(3 Pt 1):737-743.