老年支气管哮喘患者呼出气一氧化氮与肺功能的相关性

Correlation Between Fractional Exhaled Nitric Oxide and Pulmonary Function of Bronchial Asthma in Elderly Patients

目的探讨检测呼出气一氧化氮(FeNO)对于诊治老年支气管哮喘的意义。方法 120例老年支气管哮喘患者进行FeNO、一秒用力呼气容积占预计值百分比(FEV1%)等指标检测,其中60例为急性发作患者、60例为哮喘缓解组,将检测结果与60例健康体检者(对照组)进行比较。结果三组FeNO检测结果 :哮喘急性发作组>哮喘缓解组>对照组,差异均具有统计学意义(P<0.01)。哮喘急性发作组FEV1%明显低于另两组,差异具有统计学意义(P<0.01)。结论老年支气管哮喘患者FeNO指标明显升高,哮喘急性发作患者FEV_1%与FeNO水平呈明显负相关,说明FeNO检测对老年支气管哮喘的诊治有较好的指导意义。

Objective To explore the value of correlation between exhaled nitric oxide （FeNO） for bronchial asthma in elderly patients. Methods 120 cases of aged bronchial asthma patients were chosen to exam the index of FeNO and FEV1%. 60 cases of them were acute episode patients;Another 60 cases were asthmatic remission group. The detection results were compared with that of 60 healthy subjects （control group）. Results The results of three FeNO examination showed：acute episode group＆gt;asthmatic remission group＆gt;control group, there were significant differences between the three groups （P〈0.01）. FEV1%in acute episode group was lower than that in the other two groups;The differences between two groups were statistically signiifcant （P〈0.01）. Conclusion The level of FeNO increased signiifcantly acute episode of bronchial asthma. The level of FEV1%in acute episode of bronchial asthma was significantly negatively with the level of FeNO. FeNO has directive signiifcance for diagnosing aged bronchial asthma patients.