50例乙型病毒肝炎患者临床应用恩替卡韦进行治疗的有效性评价

Evaluation of Clinical Application of Entecavir for 50 Cases of Hepatitis B Patients

目的研究50例乙型病毒肝炎(乙肝)患者临床应用恩替卡韦进行治疗的有效性。方法选取我院50例乙肝患者,随机分为观察组和对照组,每组各25例患者,观察组采用恩替韦卡进行治疗,对照组采用拉米夫定治疗,对比两组治疗前后肝功能指标、超声影像学指标等的变化以及治疗后HBV-DNA滴度与转阴率及不良反应。结果观察组与对照组肝功能指标(ALT、ALB及TBil)对比,差异均具有统计学意义(P<0.05,P<0.01)。结论恩替卡韦对乙肝患者具有显著的疗效,安全性更高。

Objective To study the efficacy of ETV in the treatment of hepatitis b patients. Methods Chose 50 hepatitis b patients in our hospital were divided into two control group and obervation group with a simple random, 25 cases in each group. Control group was treat with lamivudine, and observation group was given entecavir. To compare the change in liver function, ultrasound imaging index before and after treatment. Results The difference of liver function（ALT, ALB and TBil） in two groups was statistically signiifcant before and after treatment （P〈0.05, P〈0.01）, and the difference between the two groups after treatment of these indicators was also statistically signiifcance （P〈0.05）. Conclusion Compared with LAM, ETV in the treatment of chronic hepatitis B has more signiifcant effect and safety.