室间隔缺损患儿早期心血管功能异常评估与NT-proBNP的关系研究

Relationship of NT-ProBNP in Early Cardiovascular Dysfunction Assessment in Children with Ventricular Septal Defect

目的:探讨氨基末端B型脑钠肽(NT-pro BNP)与室间隔缺损患儿早期心血管功能异常的关系。方法:选取我院心血管内科收治的先天性心脏病(室间隔缺损)患儿98例,依据小儿心衰ROSS评分分为心衰组41例(评分≥3分)和非心衰组57例(<3分),选取同期进行儿童保健的健康儿童40例作为健康组,检测并比较各组的心功能指标及相关实验室指标。结果:心衰组患儿血浆lg BNP、lg NT-pro BNP水平高于非心衰组患儿和健康组儿童(P<0.05),非心衰组患儿血浆lg BNP、lg NT-pro BNP水平高于健康组儿童(P<0.05)。心衰组患儿的LVEF、LVSF、LVCO低于非心衰组患儿和健康组儿童(P<0.05),LVEDDI、Tie指数高于非心衰组患儿和健康组儿童(P<0.05);非心衰组患儿的Tie指数高于健康组儿童(P<0.05)。lg NT-pro BNP水平与LVEF、LVSF、LVCO呈负相关(P<0.05),lg NT-pro BNP水平与LVEDDI、Tie指数呈正相关(P<0.05)。结论:NT-pro BNP与室间隔缺损患儿早期心血管功能异常具有显著的相关性,是评估室间隔缺损患儿心衰的可靠指标。

Objective： To investigate the relationship of N-terminal brain natriuretic peptide（ NT-pro BNP） and early cardiovascular dysfunction in children with ventricular septal defect. Methods： Ninety eight children with ventricular septal defect were selected in cardiovascular department of our hospital,according to the pediatric heart failure ROSS score,all children were divided into heart failure group（ 41 cases,≥3 points） and non heart failure group（ 57 cases, 〈3 points）,selected the healthy children in same period as healthy group（ 40 cases）,the cardiac function indexes and laboratory indexes of children were detected and compared. Results： The levels of lg BNP,lg NT-pro BNP in heart failure group were significantly higher than those in non heart failure group and healthy group（ P〈0.05）. The levels of lg BNP,lg NT-pro BNP in non heart failure group were significantly higher than those in healthy group（ P〈0. 05）. The LVSF,LVCO and LVEF in heart failure group were significantly lower than those in non heart failure group and healthy group（ P〈0.05）,Tie index and LVEDDI were significantly higher than those in non heart failure group and healthy group（ P〈0.05）,and the Tie index in non heart failure group was significantly higher than that in healthy group（ P〈0.05）. The levels of lg NT-pro BNP and LVSF,LVCO,LVEF showed significant negative correlation（ P〈0.05）,the levels of lg NT-pro BNP and LVEDDI,Tie index were significantly positive correlation（ P〈0.05）. Conclusion： The relationship between NT-pro BNP and early cardiovascular dysfunction is a reliable indicator of heart failure in children with ventricular septal defect.