消化系肿瘤侵袭转移过程中整合素与EMT的相互关系

Relationship between integrin and epithelial-mesenchymal transition during invasion and metastasis of digestive system carcinomas

消化系恶性肿瘤发生侵袭、转移是导致其治疗效果不佳、预后差的主要原因.许多研究表明,上皮间质化(mesenchymal transition,EMT)在肿瘤的侵袭和转移过程中具有重要作用,其主要特征为E-钙黏蛋白(E-cadherins,E-cad)的表达下调和细胞与细胞外基质间黏附力的下降.大量研究发现,整合素(integrin)也与肿瘤的侵袭和转移密切相关,整合素一方面在细胞与细胞间及细胞与细胞外基质间的黏附中发挥作用,另一方面还通过介导多种信号转导通路,直接或间接的参与EMT.目前,有关消化系恶性肿瘤侵袭转移过程中整合素和EMT的作用机制研究均呈"碎片化",缺乏"整体化"的系列研究,本文就肿瘤侵袭转移过程中整合素与EMT的相互关系作一述评.

Invasion and metastasis are distinctive features of malignant tumors of the digestive system.Studies show that epithelial-mesenchymal transition（EMT）,a conversion process with the loss of epithelial cell features and the gain of mesenchymal phenotype,has been recognized as a key element of invasion and metastasis of malignancies.When EMT occurs,downregulation of E-cadherins and loss of adhesion in extracellular matrix play critical roles,which are regarded as important indicators in the assessment of EMT.Integrin,one of cell adhesion molecule families,is involved in EMT directly or indirectly through mediating either adhesion among cells and between cells and extracellular matrix,or signal pathways.This paper summarizes the relationship between EMT and integrin.