次氯酸荧光探针的研究进展

Recent Progress in Fluorescent Probes for the Detection of Hypochlorous Acid

次氯酸(HCl O)是生物体内重要的活性氧(ROS)之一,在人类免疫功能系统中扮演着重要的角色,有助于对入侵细菌和病原体进行破坏.然而,过量的次氯酸或次氯酸盐会导致组织损伤和一系列疾病,如动脉硬化、关节炎和癌症等.因此,快速、灵敏、选择性检测生物样品中的HCl O相当重要.近年来,由于具备操作简单、检测限低、低毒性、高灵敏度和高选择性等多种优势,荧光探针方法检测次氯酸的研究得到了快速发展.按照不同的荧光基团综述了近几年HCl O荧光探针的设计、合成与应用进展.

Hypochlorous acid （HCIO） is one of the biologically important reactive oxygen species （ROS）, which plays important roles in the human immune defence system, and contributes to the destruction of invading bacteria and pathogens. But excessive formation of HCIO can lead to tissue damage and a series of human diseases, such as atherosclerosis, arthritis and even cancers, etc. Therefore, a rapid, sensitive, and selective detection of HC10 in biological samples is important. In recent years, fluorescent probes for HC10 have been developed due to various advantages such as simplicity of operation, lower limit of detection, low toxicity, high sensitivity and selectivity. A general overview of the recent research on the design, synthesis and application of fluorescent probes for hypochlorous acid is provided.