镍催化芳基三氟甲磺酸酯对醛的加成反应及偶联反应

Nickel-Catalyzed Addition and Coupling Reaction of Aryl Triflates to Aldehydes

对芳基三氟甲磺酸酯对醛的加成或偶联反应进行了研究.以Ni(dppe)Br_2为催化剂,在锌粉存在下,芳基三氟甲磺酸酯与醛在甲醇溶剂中发生加成反应,在四氢呋喃中发生偶联反应,分别以中等到良好的收率获得芳基甲醇化合物或芳基甲酮化合物.

The nickel-catalyzed addition and coupling reaction between aryl triflates and aldehydes were developed. The reactions proceed smoothly in the presence of zinc powder with the use of 10 mol% Ni（dppe）Br2 as a catalyst. A range of aryl methanols and aryl ketones were isolated respectively in moderate to good yields in MeOH and THF solvent via direct addition or coupling reactions. Aliphatic and aromatic aldehydes were involved in this reaction, showing a broad substrate scope.