摘要
成功开发了由铁粉促进“一锅法”合成1-苯基苯并咪唑类化合物的简易合成方法,以取代邻硝基二苯胺为原料,液体有机酸为溶剂,在铁粉作用下还原并直接环合生成1-苯基苯并咪唑类化合物,产率80%-93%,通过高效液相色谱(HPLC)监测分析反应进程,探讨反应的机理,并确定了最佳反应条件.该合成方法条件温和,操作简单,原料易得,产率较高,为该类化合物的合成提供了一种新的便利方法.
An easy and efficient "one-pot" synthetic method facilitated by Fe to synthesize substituted 1-phenyl-lH-benzimidazole has been developed successfully. By using liquid organic acid as solvent, 2-nitro-N-phenylaniline is converted to sub- stituted 1-phenyl-1H-benzimidazole directly after reduction and cyclization catalyzed by Fe, with the yield of 80%-92%. Through the application of high performance liquid chromatography (HPLC) detection, the effects of the amount of solvent, the type of liquid organic acid, temperature and reaction time on the "one-pot" reaction have been fully investigated, as well as the reaction mechanism. The "one-pot" method proposed here has multiple advantages, such as mild condition, easy procedure, cheap ingredients and high yield, which provide a newly convenient synthetic route.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2016年第7期1672-1676,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21102184)
高等学校博士学科点专项科研基金(No.20110162120033)资助项目~~
关键词
一锅法
1-苯基苯并咪唑
铁粉促进
反应机理
one-pot synthesis
1-phenyl-1H-benzimidazole
Fe catalysis
reaction mechanism