776例孕早期妇女甲状腺功能筛查结果分析

Analysis of thyroid function screening results in 776 cases of early pregnant women

目的探索甲状腺疾病在妊娠早期的发生率和特点,为优生优育提供科学依据。方法运用化学发光免疫分析法检测776例妊娠早期(<12^(+6)周)妇女(试验组)和100例非妊娠育龄妇女(对照组)血清促甲状腺激素(TSH)、游离甲状腺激素(FT4)、游离三碘甲状腺原氨酸(FT3)和甲状腺过氧化物酶抗体(TPO-Ab)的浓度,根据妊娠早期与非妊娠育龄妇女的不同诊断标准分析检测结果。结果试验组的TSH、FT4和TPO-Ab血清浓度与对照组的差异均有统计学意义(P<0.05)。妊娠早期妇女的甲状腺疾病总发生率达35.05%,明显高于非妊娠育龄妇女(15.00%),差异有统计学意义(P<0.05)。试验组的孕妇所患甲状腺疾病主要为甲状腺功能减退(9.28%)和亚临床甲状腺功能减退(22.94%),与对照组妇女比较差异有统计学意义(P<0.05)。结论妊娠早期甲状腺疾病的发生率高,可导致出生缺陷;因此,要重视对妊娠早期甲状腺疾病的筛查,提供优生优育理论依据。

Objective To explore the incidence and characteristics of thyroid disease in early pregnancy and to provide a scientific basis for eugenics .Methods The chemiluminescence immunoassay was used to detect the concentrations of serum thyrotropin （TSH） ,free thyroxine （FT4） ,triiodothyronine （FT3） and thyroid peroxidase antibody （TPOAb） in 776 early pregnant women （〈12＋6 weeks ,experiment group） and 100 non‐pregnant child‐bearing women （control group） .The test results were analyzed accord‐ing to the different diagnostic criteria of early pregnancy and non‐pregnant childbearing women .Results The serum concentrations of TSH ,FT4 and TPO‐Ab had statistical differences between the experimental group and the control group （P〈0 .05） .The inci‐dence rate of thyroid diseases in early pregnant women was 35 .05% ,which was significantly higher than 15 .00% in non‐pregnant childbearing women ,and the difference was statistically significant （P〈0 .05） .The thyroid diseases in pregnant women of the ex‐perimental group were mainly hypothyroidism （9 .28% ） and sub‐clinical hypothyroidism （22 .94% ） ,compared with the control group ,the difference was statistically significant（P〈0 .05） .Conclusion Early pregnancy has high incidence rate of thyroid disease , which can lead to birth defects .Therefore ,screening early gestation thyroid diseases should be paid attention to provide theoretical basis for eugenics .